人 HUWE1 抗体对
01AB01721
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 (HUWE1) is a large HECT-type E3 ubiquitin ligase that plays a central role in cellular stress responses and protein quality control. It features a massive α-solenoid ring scaffold with multiple interaction modules, including WWE and UBA domains, which allow it to target a broad range of substrates for proteasomal degradation. HUWE1 regulates over 40 substrates involved in the DNA damage response, transcription, apoptosis, and autophagy. Pathologically, germline and de novo variants in HUWE1 are linked to X-linked neurodevelopmental disorders. Additionally, its dysregulation is implicated in the progression of various cancers, positioning HUWE1 as an emerging target for anticancer drug development.
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技术参数
- 靶点基因名
- HUWE1
- 基因别名
- KIAA0312; KIAA1578; UREB1
- 蛋白别名
- HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1; HUWE1
- UniProt
- Q7Z6Z7
- 物种
- Human
产品详情
- 靶点名称
- HUWE1
- 蛋白名称
- HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
- 蛋白别名
- E3 ubiquitin-protein ligase HUWE1; ARF-binding protein 1; ARF-BP1; HECT; UBA and WWE domain-containing protein 1; HECT-type E3 ubiquitin transferase HUWE1; Homologous to E6AP carboxyl terminus homologous protein 9; HectH9; Large structure of UREB1; LASU1; Mcl-1 ubiquitin ligase E3; Mule; Upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1
- 靶点基因名
- HUWE1
- 基因别名
- KIAA0312; KIAA1578; UREB1
- UniProt
- Q7Z6Z7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 (HUWE1) is a large HECT-type E3 ubiquitin ligase that plays a central role in cellular stress responses and protein quality control. It features a massive α-solenoid ring scaffold with multiple interaction modules, including WWE and UBA domains, which allow it to target a broad range of substrates for proteasomal degradation. HUWE1 regulates over 40 substrates involved in the DNA damage response, transcription, apoptosis, and autophagy. Pathologically, germline and de novo variants in HUWE1 are linked to X-linked neurodevelopmental disorders. Additionally, its dysregulation is implicated in the progression of various cancers, positioning HUWE1 as an emerging target for anticancer drug development.