人 HTR2C 抗体对
01AB02670
5-hydroxytryptamine receptor 2C (HTR2C) is a class A G protein-coupled receptor for serotonin primarily expressed in the central nervous system, including the hypothalamus. It features a seven-transmembrane structure and couples to Gq/11 proteins to activate phospholipase C-beta, leading to intracellular calcium mobilization and protein kinase C activation. The HTR2C mRNA undergoes extensive RNA editing and alternative splicing to produce isoforms with varying constitutive activities. Functionally, the receptor modulates dopaminergic and serotonergic circuits to regulate appetite, energy homeostasis, and anxiety. Clinically, HTR2C is a well-established factor in obesity and antipsychotic-induced weight gain. It is also implicated in mood and anxiety disorders and serves as a primary pharmacological target for several anti-obesity and psychotropic medications.
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技术参数
- 靶点基因名
- HTR2C
- 基因别名
- HTR1C
- 蛋白别名
- 5-hydroxytryptamine receptor 2C; HTR2C
- UniProt
- P28335
- 物种
- Human
产品详情
- 靶点名称
- HTR2C
- 蛋白名称
- 5-hydroxytryptamine receptor 2C
- 蛋白别名
- 5-hydroxytryptamine receptor 2C; 5-HT-2C; 5-HT2C; 5-HTR2C; 5-hydroxytryptamine receptor 1C; 5-HT-1C; 5-HT1C; Serotonin receptor 2C
- 靶点基因名
- HTR2C
- 基因别名
- HTR1C
- UniProt
- P28335
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
5-hydroxytryptamine receptor 2C (HTR2C) is a class A G protein-coupled receptor for serotonin primarily expressed in the central nervous system, including the hypothalamus. It features a seven-transmembrane structure and couples to Gq/11 proteins to activate phospholipase C-beta, leading to intracellular calcium mobilization and protein kinase C activation. The HTR2C mRNA undergoes extensive RNA editing and alternative splicing to produce isoforms with varying constitutive activities. Functionally, the receptor modulates dopaminergic and serotonergic circuits to regulate appetite, energy homeostasis, and anxiety. Clinically, HTR2C is a well-established factor in obesity and antipsychotic-induced weight gain. It is also implicated in mood and anxiety disorders and serves as a primary pharmacological target for several anti-obesity and psychotropic medications.