人 HTR1B 抗体对
01AB03422
5-hydroxytryptamine receptor 1B (HTR1B) is a G-protein-coupled receptor for serotonin that primarily signals through Gi/o proteins to inhibit adenylate cyclase activity. It is widely distributed in the central nervous system, particularly in the basal ganglia, striatum, and hippocampus, as well as in vascular smooth muscle and retinal ganglion cells. By acting as a presynaptic autoreceptor or heteroreceptor, HTR1B modulates the release of various neurotransmitters, including serotonin, dopamine, and acetylcholine, thereby influencing mood, aggression, pain perception, and appetite. It also plays a significant role in regulating vasoconstriction and thermoregulation. Clinically, HTR1B is strongly associated with obsessive-compulsive disorder and has been implicated in the pathophysiology of Prinzmetal angina due to its effects on vascular tone. Additionally, its presence in the retina is critical for visual function, with deficiencies linked to reduced contrast sensitivity and visual acuity, highlighting its broad physiological and clinical importance.
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技术参数
- 靶点基因名
- HTR1B
- 基因别名
- HTR1DB
- 蛋白别名
- 5-hydroxytryptamine receptor 1B; HTR1B
- UniProt
- P28222
- 物种
- Human
产品详情
- 靶点名称
- HTR1B
- 蛋白名称
- 5-hydroxytryptamine receptor 1B
- 蛋白别名
- 5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT1B; S12; Serotonin 1D beta receptor; 5-HT-1D-beta; Serotonin receptor 1B
- 靶点基因名
- HTR1B
- 基因别名
- HTR1DB
- UniProt
- P28222
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
5-hydroxytryptamine receptor 1B (HTR1B) is a G-protein-coupled receptor for serotonin that primarily signals through Gi/o proteins to inhibit adenylate cyclase activity. It is widely distributed in the central nervous system, particularly in the basal ganglia, striatum, and hippocampus, as well as in vascular smooth muscle and retinal ganglion cells. By acting as a presynaptic autoreceptor or heteroreceptor, HTR1B modulates the release of various neurotransmitters, including serotonin, dopamine, and acetylcholine, thereby influencing mood, aggression, pain perception, and appetite. It also plays a significant role in regulating vasoconstriction and thermoregulation. Clinically, HTR1B is strongly associated with obsessive-compulsive disorder and has been implicated in the pathophysiology of Prinzmetal angina due to its effects on vascular tone. Additionally, its presence in the retina is critical for visual function, with deficiencies linked to reduced contrast sensitivity and visual acuity, highlighting its broad physiological and clinical importance.