人 HSD11B1 抗体对
01AB00842
Hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1) is a microsomal enzyme that catalyzes the reversible conversion of cortisol to inactive cortisone, playing a crucial role in glucocorticoid metabolism. It is highly expressed in key metabolic tissues such as liver, adipose tissue, and the central nervous system. HSD11B1 is encoded by the HSD11B1 gene located on chromosome 1q32-q41 and consists of 292 amino acid residues with a molecular weight of 32.4 kDa. The enzyme belongs to the short-chain dehydrogenase family and requires NADPH as a cofactor. HSD11B1 has been implicated in various metabolic disorders, including obesity, insulin resistance, and type 2 diabetes. Increased HSD11B1 activity in adipose tissue has been associated with central obesity and metabolic syndrome. Additionally, recent studies have suggested a potential role for HSD11B1 in the pathogenesis of sarcopenia, with its expression negatively correlating with muscle mass in sarcopenic patients.
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技术参数
- 靶点基因名
- HSD11B1
- 基因别名
- HSD11; HSD11L; SDR26C1
- 蛋白别名
- hydroxysteroid 11-beta dehydrogenase 1; HSD11B1
- UniProt
- P28845
- 物种
- Human
产品详情
- 靶点名称
- HSD11B1
- 蛋白名称
- hydroxysteroid 11-beta dehydrogenase 1
- 蛋白别名
- 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; 7-oxosteroid reductase; Corticosteroid 11-beta-dehydrogenase isozyme 1; Short chain dehydrogenase/reductase family 26C member 1
- 靶点基因名
- HSD11B1
- 基因别名
- HSD11; HSD11L; SDR26C1
- UniProt
- P28845
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1) is a microsomal enzyme that catalyzes the reversible conversion of cortisol to inactive cortisone, playing a crucial role in glucocorticoid metabolism. It is highly expressed in key metabolic tissues such as liver, adipose tissue, and the central nervous system. HSD11B1 is encoded by the HSD11B1 gene located on chromosome 1q32-q41 and consists of 292 amino acid residues with a molecular weight of 32.4 kDa. The enzyme belongs to the short-chain dehydrogenase family and requires NADPH as a cofactor. HSD11B1 has been implicated in various metabolic disorders, including obesity, insulin resistance, and type 2 diabetes. Increased HSD11B1 activity in adipose tissue has been associated with central obesity and metabolic syndrome. Additionally, recent studies have suggested a potential role for HSD11B1 in the pathogenesis of sarcopenia, with its expression negatively correlating with muscle mass in sarcopenic patients.