人 HPGDS 抗体对
01AB04052
Hematopoietic prostaglandin D synthase (HPGDS) is a bifunctional enzyme encoded by the HPGDS gene located on chromosome 4, primarily involved in the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2), a crucial mediator in various physiological processes including smooth muscle contraction and immune responses. This enzyme exhibits glutathione transferase activity, utilizing glutathione as a cofactor, and plays a significant role in modulating inflammatory responses, particularly through its anti-inflammatory effects in conditions such as asthma and allergic reactions. Variants of HPGDS have been linked to differential disease susceptibilities, including colorectal cancer risk, highlighting its potential as a therapeutic target. Additionally, HPGDS is expressed in various tissues, particularly in mast cells and antigen-presenting cells, suggesting its involvement in immune regulation and tissue homeostasis.
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技术参数
- 靶点基因名
- HPGDS
- 基因别名
- GSTS; PGDS; PTGDS2
- 蛋白别名
- hematopoietic prostaglandin D synthase; HPGDS
- UniProt
- O60760
- 物种
- Human
产品详情
- 靶点名称
- HPGDS
- 蛋白名称
- hematopoietic prostaglandin D synthase
- 蛋白别名
- Hematopoietic prostaglandin D synthase; H-PGDS; GST class-sigma; Glutathione S-transferase; Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; Prostaglandin-H2 D-isomerase
- 靶点基因名
- HPGDS
- 基因别名
- GSTS; PGDS; PTGDS2
- UniProt
- O60760
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Hematopoietic prostaglandin D synthase (HPGDS) is a bifunctional enzyme encoded by the HPGDS gene located on chromosome 4, primarily involved in the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2), a crucial mediator in various physiological processes including smooth muscle contraction and immune responses. This enzyme exhibits glutathione transferase activity, utilizing glutathione as a cofactor, and plays a significant role in modulating inflammatory responses, particularly through its anti-inflammatory effects in conditions such as asthma and allergic reactions. Variants of HPGDS have been linked to differential disease susceptibilities, including colorectal cancer risk, highlighting its potential as a therapeutic target. Additionally, HPGDS is expressed in various tissues, particularly in mast cells and antigen-presenting cells, suggesting its involvement in immune regulation and tissue homeostasis.