人 HMOX2 抗体对
01AB00265
Heme oxygenase 2 (HMOX2) is a constitutive enzyme crucial for heme catabolism, converting heme into biliverdin, which is further metabolized to bilirubin, and releasing carbon monoxide (CO) and ferrous iron. HMOX2 is expressed in various tissues, particularly in the brain, testes, and endothelial cells, and plays a vital role in heme homeostasis, antioxidation, anti-inflammation, and metabolic regulation. The enzyme is encoded by the HMOX2 gene and has been associated with diseases such as neonatal jaundice and gastroparesis. HMOX2 genetic variants have also been linked to conditions like polycystic ovary syndrome (PCOS), essential tremors, multiple sclerosis, and age-related macular degeneration. The enzyme's activity is barely regulated at the transcriptional and translational levels, but it is essential for cellular protection and oxygen response.
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技术参数
- 靶点基因名
- HMOX2
- 基因别名
- HO2
- 蛋白别名
- heme oxygenase 2; HMOX2
- UniProt
- P30519
- 物种
- Human
产品详情
- 靶点名称
- HMOX2
- 蛋白名称
- heme oxygenase 2
- 蛋白别名
- Heme oxygenase 2; HO-2) [Cleaved into: Heme oxygenase 2 soluble form]
- 靶点基因名
- HMOX2
- 基因别名
- HO2
- UniProt
- P30519
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Heme oxygenase 2 (HMOX2) is a constitutive enzyme crucial for heme catabolism, converting heme into biliverdin, which is further metabolized to bilirubin, and releasing carbon monoxide (CO) and ferrous iron. HMOX2 is expressed in various tissues, particularly in the brain, testes, and endothelial cells, and plays a vital role in heme homeostasis, antioxidation, anti-inflammation, and metabolic regulation. The enzyme is encoded by the HMOX2 gene and has been associated with diseases such as neonatal jaundice and gastroparesis. HMOX2 genetic variants have also been linked to conditions like polycystic ovary syndrome (PCOS), essential tremors, multiple sclerosis, and age-related macular degeneration. The enzyme's activity is barely regulated at the transcriptional and translational levels, but it is essential for cellular protection and oxygen response.