人 HLTF 抗体对
01AB03186
Helicase-like transcription factor (HLTF) is a multifunctional DNA translocase of the SWI/SNF family, possessing ATP-dependent helicase and E3 ubiquitin ligase activities. It contains a HIRAN domain for recognizing DNA structures, a SWI/SNF-type ATPase domain, and a RING finger domain. HLTF is critical for genome stability, functioning as the human homolog of yeast RAD5 in error-free post-replication repair. It is recruited to stalled replication forks, where it polyubiquitinates PCNA and promotes fork reversal, facilitating DNA damage tolerance. In oncology, HLTF acts as a tumor suppressor; its promoter is frequently hypermethylated in colorectal and gastric cancers, and its inactivation leads to genomic instability and altered sensitivity to DNA-damaging agents.
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技术参数
- 靶点基因名
- HLTF
- 基因别名
- HIP116A; RNF80; SMARCA3; SNF2L3; ZBU1
- 蛋白别名
- helicase like transcription factor; HLTF
- UniProt
- Q14527
- 物种
- Human
产品详情
- 靶点名称
- HLTF
- 蛋白名称
- helicase like transcription factor
- 蛋白别名
- Helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3
- 靶点基因名
- HLTF
- 基因别名
- HIP116A; RNF80; SMARCA3; SNF2L3; ZBU1
- UniProt
- Q14527
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Helicase-like transcription factor (HLTF) is a multifunctional DNA translocase of the SWI/SNF family, possessing ATP-dependent helicase and E3 ubiquitin ligase activities. It contains a HIRAN domain for recognizing DNA structures, a SWI/SNF-type ATPase domain, and a RING finger domain. HLTF is critical for genome stability, functioning as the human homolog of yeast RAD5 in error-free post-replication repair. It is recruited to stalled replication forks, where it polyubiquitinates PCNA and promotes fork reversal, facilitating DNA damage tolerance. In oncology, HLTF acts as a tumor suppressor; its promoter is frequently hypermethylated in colorectal and gastric cancers, and its inactivation leads to genomic instability and altered sensitivity to DNA-damaging agents.