人 HIPK2 抗体对
01AB02475
Homeodomain interacting protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase that plays a pivotal role in regulating cell proliferation, differentiation, and apoptosis. It features a conserved bilobal kinase domain and multiple regulatory regions, including a homeodomain-interacting domain and a speckle-retention signal for nuclear localization. HIPK2 functions as a critical sensor of DNA damage, where it phosphorylates the tumor suppressor p53 at Ser46 to induce apoptosis. It also interacts with and modulates various other transcription factors and co-regulators to control the cell cycle and stress responses. Clinically, HIPK2 is recognized as a potent tumor suppressor; however, its dysregulation or hyperactivity is frequently observed in various cancers and chronic fibrotic diseases.
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技术参数
- 靶点基因名
- HIPK2
- 蛋白别名
- homeodomain interacting protein kinase 2; HIPK2
- UniProt
- Q9H2X6
- 物种
- Human
产品详情
- 靶点名称
- HIPK2
- 蛋白名称
- homeodomain interacting protein kinase 2
- 蛋白别名
- Homeodomain-interacting protein kinase 2; hHIPk2
- 靶点基因名
- HIPK2
- UniProt
- Q9H2X6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Homeodomain interacting protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase that plays a pivotal role in regulating cell proliferation, differentiation, and apoptosis. It features a conserved bilobal kinase domain and multiple regulatory regions, including a homeodomain-interacting domain and a speckle-retention signal for nuclear localization. HIPK2 functions as a critical sensor of DNA damage, where it phosphorylates the tumor suppressor p53 at Ser46 to induce apoptosis. It also interacts with and modulates various other transcription factors and co-regulators to control the cell cycle and stress responses. Clinically, HIPK2 is recognized as a potent tumor suppressor; however, its dysregulation or hyperactivity is frequently observed in various cancers and chronic fibrotic diseases.