人 HIBADH 抗体对
01AB03061
3-hydroxyisobutyrate dehydrogenase (HIBADH) is a NAD+-dependent oxidoreductase located in the mitochondrial matrix. It catalyzes the reversible oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde, a critical step in the catabolism of the branched-chain amino acid L-valine. As a member of the short-chain dehydrogenase/reductase family, HIBADH is essential for maintaining branched-chain amino acid homeostasis and energy metabolism. Genetic associations suggest a potential link between HIBADH dysfunction and metabolic conditions such as abdominal obesity-metabolic syndrome and renal tubular disorders, implicating it in systemic energy balance regulation.
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技术参数
- 靶点基因名
- HIBADH
- 蛋白别名
- 3-hydroxyisobutyrate dehydrogenase; HIBADH
- UniProt
- P31937
- 物种
- Human
产品详情
- 靶点名称
- HIBADH
- 蛋白名称
- 3-hydroxyisobutyrate dehydrogenase
- 蛋白别名
- 3-hydroxyisobutyrate dehydrogenase; mitochondrial; HIBADH
- 靶点基因名
- HIBADH
- UniProt
- P31937
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
3-hydroxyisobutyrate dehydrogenase (HIBADH) is a NAD+-dependent oxidoreductase located in the mitochondrial matrix. It catalyzes the reversible oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde, a critical step in the catabolism of the branched-chain amino acid L-valine. As a member of the short-chain dehydrogenase/reductase family, HIBADH is essential for maintaining branched-chain amino acid homeostasis and energy metabolism. Genetic associations suggest a potential link between HIBADH dysfunction and metabolic conditions such as abdominal obesity-metabolic syndrome and renal tubular disorders, implicating it in systemic energy balance regulation.