人 HGH1 抗体对
01AB02206
HGH1 cochaperone (HGH1) is a highly conserved protein that functions as a specialized chaperone in the biogenesis of eukaryotic translation elongation factor 2 (eEF2), cooperating with major chaperone systems such as TRiC and Hsp90 to ensure proper folding and stability of this essential translation factor. HGH1 physically bridges eEF2 with these chaperone complexes, facilitating its maturation and preventing aggregation or degradation. Beyond its role in translation, HGH1 has been implicated in human cancers, where elevated expression is associated with poor prognosis, increased cell proliferation, and an immune-deficient tumor microenvironment, suggesting a role in tumorigenesis and immune modulation. Genetic alterations, particularly copy number variations, are common in HGH1 across various cancers, and its overexpression correlates with reduced immune cell infiltration and diminished response to immunotherapy. Diseases linked to HGH1 include Hermansky-Pudlak Syndrome 1 and Maturity-Onset Diabetes of the Young, Type 3, highlighting its importance in cellular homeostasis and disease pathogenesis.
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技术参数
- 靶点基因名
- HGH1
- 基因别名
- C8orf30A; C8orf30B; FAM203A; FAM203B
- 蛋白别名
- HGH1 cochaperone; HGH1
- UniProt
- Q9BTY7
- 物种
- Human
产品详情
- 靶点名称
- HGH1
- 蛋白名称
- HGH1 cochaperone
- 蛋白别名
- Protein HGH1 homolog
- 靶点基因名
- HGH1
- 基因别名
- C8orf30A; C8orf30B; FAM203A; FAM203B
- UniProt
- Q9BTY7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
HGH1 cochaperone (HGH1) is a highly conserved protein that functions as a specialized chaperone in the biogenesis of eukaryotic translation elongation factor 2 (eEF2), cooperating with major chaperone systems such as TRiC and Hsp90 to ensure proper folding and stability of this essential translation factor. HGH1 physically bridges eEF2 with these chaperone complexes, facilitating its maturation and preventing aggregation or degradation. Beyond its role in translation, HGH1 has been implicated in human cancers, where elevated expression is associated with poor prognosis, increased cell proliferation, and an immune-deficient tumor microenvironment, suggesting a role in tumorigenesis and immune modulation. Genetic alterations, particularly copy number variations, are common in HGH1 across various cancers, and its overexpression correlates with reduced immune cell infiltration and diminished response to immunotherapy. Diseases linked to HGH1 include Hermansky-Pudlak Syndrome 1 and Maturity-Onset Diabetes of the Young, Type 3, highlighting its importance in cellular homeostasis and disease pathogenesis.