人 HES4 抗体对
01AB00518
HES4 (Hairy and Enhancer of Split 4) is a basic helix-loop-helix (bHLH) transcription factor encoded by a gene on human chromosome 1. It plays a key role in developmental processes, particularly in T-cell differentiation through Notch1 signaling, and in bone formation. Structurally, HES4 consists of 221 amino acids and features a bHLH domain critical for DNA binding and transcriptional regulation. Clinically, HES4 has been implicated in several diseases. In osteosarcoma, its overexpression correlates with aggressive tumor behavior and poor prognosis. Additionally, epigenetic dysregulation of HES4 is associated with Huntington's disease (HD), where hypermethylation of its promoter leads to altered neuronal gene expression and striatal degeneration. Furthermore, elevated HES4 expression in hepatocellular carcinoma (HCC) is linked to poor outcomes, highlighting its potential as a prognostic marker and therapeutic target.
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技术参数
- 靶点基因名
- HES4
- 基因别名
- BHLHB42
- 蛋白别名
- hes family bHLH transcription factor 4; HES4
- UniProt
- Q9HCC6
- 物种
- Human
产品详情
- 靶点名称
- HES4
- 蛋白名称
- hes family bHLH transcription factor 4
- 蛋白别名
- Transcription factor HES-4; hHES4; Class B basic helix-loop-helix protein 42; bHLHb42; Hairy and enhancer of split 4; bHLH factor Hes4
- 靶点基因名
- HES4
- 基因别名
- BHLHB42
- UniProt
- Q9HCC6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
HES4 (Hairy and Enhancer of Split 4) is a basic helix-loop-helix (bHLH) transcription factor encoded by a gene on human chromosome 1. It plays a key role in developmental processes, particularly in T-cell differentiation through Notch1 signaling, and in bone formation. Structurally, HES4 consists of 221 amino acids and features a bHLH domain critical for DNA binding and transcriptional regulation. Clinically, HES4 has been implicated in several diseases. In osteosarcoma, its overexpression correlates with aggressive tumor behavior and poor prognosis. Additionally, epigenetic dysregulation of HES4 is associated with Huntington's disease (HD), where hypermethylation of its promoter leads to altered neuronal gene expression and striatal degeneration. Furthermore, elevated HES4 expression in hepatocellular carcinoma (HCC) is linked to poor outcomes, highlighting its potential as a prognostic marker and therapeutic target.