人 HCN1 抗体对
01AB03226
Hyperpolarization activated cyclic nucleotide gated potassium channel 1 (HCN1) is a membrane cation channel that mediates the hyperpolarization-activated funny current (Ih), a key driver of pacemaker activity and rhythmic firing in neurons and cardiomyocytes. The channel functions as a homo- or heterotetramer and interacts with auxiliary subunits such as KCNE2 to modulate gating kinetics. Structurally, HCN1 features a six-transmembrane voltage-gated potassium channel-like architecture with a C-terminal cyclic nucleotide-binding domain. Binding of cAMP to this domain shifts channel activation toward more depolarized potentials, enhancing excitability. In the nervous system, HCN1 is essential for dendritic integration and network oscillations. Dysfunction or genetic variants of HCN1 are well-established causes of epilepsy and various neurodevelopmental phenotypes, while its cardiac role involves the modulation of sinoatrial node automaticity.
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技术参数
- 靶点基因名
- HCN1
- 基因别名
- BCNG1
- 蛋白别名
- hyperpolarization activated cyclic nucleotide gated potassium channel 1; HCN1
- UniProt
- O60741
- 物种
- Human
产品详情
- 靶点名称
- HCN1
- 蛋白名称
- hyperpolarization activated cyclic nucleotide gated potassium channel 1
- 蛋白别名
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; Brain cyclic nucleotide-gated channel 1; BCNG-1
- 靶点基因名
- HCN1
- 基因别名
- BCNG1
- UniProt
- O60741
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Hyperpolarization activated cyclic nucleotide gated potassium channel 1 (HCN1) is a membrane cation channel that mediates the hyperpolarization-activated funny current (Ih), a key driver of pacemaker activity and rhythmic firing in neurons and cardiomyocytes. The channel functions as a homo- or heterotetramer and interacts with auxiliary subunits such as KCNE2 to modulate gating kinetics. Structurally, HCN1 features a six-transmembrane voltage-gated potassium channel-like architecture with a C-terminal cyclic nucleotide-binding domain. Binding of cAMP to this domain shifts channel activation toward more depolarized potentials, enhancing excitability. In the nervous system, HCN1 is essential for dendritic integration and network oscillations. Dysfunction or genetic variants of HCN1 are well-established causes of epilepsy and various neurodevelopmental phenotypes, while its cardiac role involves the modulation of sinoatrial node automaticity.