抗人 HBEGF 抗体对
01AB03870
Proheparin-binding EGF-like growth factor (HBEGF) is a member of the epidermal growth factor (EGF) family, synthesized as a membrane-anchored glycoprotein that plays critical roles in cellular processes such as proliferation, differentiation, and wound healing. HBEGF can be cleaved to release a soluble form that exhibits mitogenic and chemotactic properties, particularly for smooth muscle cells and fibroblasts. Its expression is highly regulated and occurs in response to various stimuli, including inflammation and tissue injury. Dysregulation of HBEGF has been implicated in several diseases: Elevated levels of HBEGF have been found in various malignancies, including breast, lung, and colorectal cancers. Additionally, HBEGF is involved in cardiovascular diseases, particularly in cardiac hypertrophy and atherosclerosis, where it mediates vascular remodeling.
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技术参数
- 靶点基因名
- HBEGF
- 基因别名
- DTR; DTS; HEGFL
- 蛋白别名
- heparin binding EGF like growth factor; HBEGF
- UniProt
- Q99075
- 物种
- Human
产品详情
- 靶点名称
- HBEGF
- 蛋白名称
- heparin binding EGF like growth factor
- 蛋白别名
- Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor; HB-EGF; HBEGF; Diphtheria toxin receptor; DT-R]
- 靶点基因名
- HBEGF
- 基因别名
- DTR; DTS; HEGFL
- UniProt
- Q99075
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Proheparin-binding EGF-like growth factor (HBEGF) is a member of the epidermal growth factor (EGF) family, synthesized as a membrane-anchored glycoprotein that plays critical roles in cellular processes such as proliferation, differentiation, and wound healing. HBEGF can be cleaved to release a soluble form that exhibits mitogenic and chemotactic properties, particularly for smooth muscle cells and fibroblasts. Its expression is highly regulated and occurs in response to various stimuli, including inflammation and tissue injury. Dysregulation of HBEGF has been implicated in several diseases: Elevated levels of HBEGF have been found in various malignancies, including breast, lung, and colorectal cancers. Additionally, HBEGF is involved in cardiovascular diseases, particularly in cardiac hypertrophy and atherosclerosis, where it mediates vascular remodeling.