人 HAVCR2 抗体对
01AB04049
Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin mucin 3 (TIM-3), is a protein encoded by the HAVCR2 gene located on chromosome 5. This receptor is part of the immunoglobulin superfamily and plays a crucial role in regulating immune responses, particularly in T-helper type 1 (Th1) cells, where it inhibits Th1-mediated autoimmune responses and promotes immunological tolerance. HAVCR2 has been implicated in various diseases, including subcutaneous panniculitis-like T-cell lymphoma and hepatitis A, and is recognized as a potential target for immunotherapy due to its involvement in tumor immunity and prognosis across multiple cancer types. Research indicates that HAVCR2 expression levels correlate with immune infiltration in tumors, suggesting its dual role as both an immune checkpoint and a biomarker for therapeutic strategies in cancer treatment.
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技术参数
- 靶点基因名
- HAVCR2
- 基因别名
- TIM3; TIMD3
- 蛋白别名
- hepatitis A virus cellular receptor 2; HAVCR2
- UniProt
- Q8TDQ0
- 物种
- Human
产品详情
- 靶点名称
- HAVCR2
- 蛋白名称
- hepatitis A virus cellular receptor 2
- 蛋白别名
- Hepatitis A virus cellular receptor 2; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3; CD antigen CD366
- 靶点基因名
- HAVCR2
- 基因别名
- TIM3; TIMD3
- UniProt
- Q8TDQ0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin mucin 3 (TIM-3), is a protein encoded by the HAVCR2 gene located on chromosome 5. This receptor is part of the immunoglobulin superfamily and plays a crucial role in regulating immune responses, particularly in T-helper type 1 (Th1) cells, where it inhibits Th1-mediated autoimmune responses and promotes immunological tolerance. HAVCR2 has been implicated in various diseases, including subcutaneous panniculitis-like T-cell lymphoma and hepatitis A, and is recognized as a potential target for immunotherapy due to its involvement in tumor immunity and prognosis across multiple cancer types. Research indicates that HAVCR2 expression levels correlate with immune infiltration in tumors, suggesting its dual role as both an immune checkpoint and a biomarker for therapeutic strategies in cancer treatment.