人 HAGH 抗体对
01AB00260
Hydroxyacylglutathione hydrolase (HAGH), also known as glyoxalase II, is an enzyme encoded by the HAGH gene in humans, located on chromosome 16. It plays a critical role in the detoxification of reactive carbonyl compounds by catalyzing the hydrolysis of S-(2-hydroxyacyl)glutathione to produce glutathione and a 2-hydroxy carboxylate, thus participating in pyruvate metabolism and cellular defense mechanisms against oxidative stress. HAGH is associated with various diseases, particularly neurodegenerative conditions like Alzheimer's disease, where its protein levels have been found to correlate with disease risk in certain genetic backgrounds. Mutations or dysregulation in HAGH activity can contribute to metabolic disorders and complications related to oxidative stress, emphasizing its importance in maintaining cellular homeostasis and preventing disease progression.
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技术参数
- 靶点基因名
- HAGH
- 基因别名
- GLO2; HAGH1
- 蛋白别名
- hydroxyacylglutathione hydrolase; HAGH
- UniProt
- Q16775
- 物种
- Human
产品详情
- 靶点名称
- HAGH
- 蛋白名称
- hydroxyacylglutathione hydrolase
- 蛋白别名
- Hydroxyacylglutathione hydrolase; mitochondrial; Glyoxalase II; Glx II
- 靶点基因名
- HAGH
- 基因别名
- GLO2; HAGH1
- UniProt
- Q16775
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Hydroxyacylglutathione hydrolase (HAGH), also known as glyoxalase II, is an enzyme encoded by the HAGH gene in humans, located on chromosome 16. It plays a critical role in the detoxification of reactive carbonyl compounds by catalyzing the hydrolysis of S-(2-hydroxyacyl)glutathione to produce glutathione and a 2-hydroxy carboxylate, thus participating in pyruvate metabolism and cellular defense mechanisms against oxidative stress. HAGH is associated with various diseases, particularly neurodegenerative conditions like Alzheimer's disease, where its protein levels have been found to correlate with disease risk in certain genetic backgrounds. Mutations or dysregulation in HAGH activity can contribute to metabolic disorders and complications related to oxidative stress, emphasizing its importance in maintaining cellular homeostasis and preventing disease progression.