人 GVINP1 抗体对
01AB02830
GTPase, very large interferon inducible pseudogene 1 (GVINP1), also functionally identified as GVIN1, encodes a very large, interferon-inducible dynamin-like GTPase. Although historically annotated as a pseudogene, the transcript encodes a cytosolic protein of approximately 209 kDa belonging to the interferon-inducible large GTPase superfamily. Upon stimulation by interferon-gamma, GVIN1 assembles into "coatomer" structures on the surface of cytosolic Gram-negative bacteria, such as Burkholderia thailandensis. In cooperation with other interferon-stimulated genes, it blocks bacterial actin-based motility by displacing actin nucleators, thereby defining an autonomous, cell-intrinsic antimicrobial defense pathway.
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技术参数
- 靶点基因名
- GVINP1
- 基因别名
- GVIN1; VLIG1
- 蛋白别名
- GTPase, very large interferon inducible pseudogene 1; GVINP1
- UniProt
- Q7Z2Y8
- 物种
- Human
产品详情
- 靶点名称
- GVINP1
- 蛋白名称
- GTPase, very large interferon inducible pseudogene 1
- 蛋白别名
- Interferon-induced very large GTPase 1; Interferon-induced very large GTPase pseudogene 1
- 靶点基因名
- GVINP1
- 基因别名
- GVIN1; VLIG1
- UniProt
- Q7Z2Y8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
GTPase, very large interferon inducible pseudogene 1 (GVINP1), also functionally identified as GVIN1, encodes a very large, interferon-inducible dynamin-like GTPase. Although historically annotated as a pseudogene, the transcript encodes a cytosolic protein of approximately 209 kDa belonging to the interferon-inducible large GTPase superfamily. Upon stimulation by interferon-gamma, GVIN1 assembles into "coatomer" structures on the surface of cytosolic Gram-negative bacteria, such as Burkholderia thailandensis. In cooperation with other interferon-stimulated genes, it blocks bacterial actin-based motility by displacing actin nucleators, thereby defining an autonomous, cell-intrinsic antimicrobial defense pathway.