人 GSTO1 抗体对
01AB01718
Glutathione S-transferase omega 1 (GSTO1) is a cytosolic enzyme that functions as a glutathione-dependent thiol transferase and dehydroascorbate reductase. It plays a vital role in maintaining cellular redox homeostasis and recycling ascorbate, while also participating in detoxification through S-(phenacyl)glutathione reductase activity. Structurally, GSTO1 features a thioredoxin-like N-terminal domain and a C-terminal domain that determines substrate specificity. It is widely expressed and modulates inflammatory signaling pathways in response to oxidative stress. Clinically, genetic polymorphisms in GSTO1 are linked to an altered risk of neurodegenerative conditions, including Alzheimer’s and Parkinson’s diseases, as well as cardiovascular disease and various cancers, likely due to impaired detoxification and redox regulation.
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技术参数
- 靶点基因名
- GSTO1
- 基因别名
- GSTTLP28
- 蛋白别名
- glutathione S-transferase omega 1; GSTO1
- UniProt
- P78417
- 物种
- Human
产品详情
- 靶点名称
- GSTO1
- 蛋白名称
- glutathione S-transferase omega 1
- 蛋白别名
- Glutathione S-transferase omega-1; GSTO-1; Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; S-(Phenacyl)glutathione reductase; SPG-R
- 靶点基因名
- GSTO1
- 基因别名
- GSTTLP28
- UniProt
- P78417
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Glutathione S-transferase omega 1 (GSTO1) is a cytosolic enzyme that functions as a glutathione-dependent thiol transferase and dehydroascorbate reductase. It plays a vital role in maintaining cellular redox homeostasis and recycling ascorbate, while also participating in detoxification through S-(phenacyl)glutathione reductase activity. Structurally, GSTO1 features a thioredoxin-like N-terminal domain and a C-terminal domain that determines substrate specificity. It is widely expressed and modulates inflammatory signaling pathways in response to oxidative stress. Clinically, genetic polymorphisms in GSTO1 are linked to an altered risk of neurodegenerative conditions, including Alzheimer’s and Parkinson’s diseases, as well as cardiovascular disease and various cancers, likely due to impaired detoxification and redox regulation.