抗人 GSTA4 抗体对
01AB01150
Glutathione S-transferase alpha 4 (GSTA4) is a phase II detoxifying enzyme involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. It catalyzes the conjugation of reduced glutathione to a wide range of exogenous and endogenous hydrophobic electrophiles, with high efficiency for 4-hydroxynonenal (4-HNE). GSTA4 is expressed in various tissues, including liver, kidney, and brain, and plays a crucial role in protecting cells from oxidative stress. The enzyme is encoded by the GSTA4 gene located on chromosome 6 in humans. GSTA4 has been implicated in several diseases, including Parkinson's disease, Alzheimer's disease, and atherosclerosis. Decreased expression of GSTA4 has been observed in burn and trauma victims, while increased expression has been noted in colorectal cancer.
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技术参数
- 靶点基因名
- GSTA4
- 蛋白别名
- glutathione S-transferase alpha 4; GSTA4
- UniProt
- O15217
- 物种
- Human
产品详情
- 靶点名称
- GSTA4
- 蛋白名称
- glutathione S-transferase alpha 4
- 蛋白别名
- Glutathione S-transferase A4; GST class-alpha member 4; Glutathione S-transferase A4-4
- 靶点基因名
- GSTA4
- UniProt
- O15217
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Glutathione S-transferase alpha 4 (GSTA4) is a phase II detoxifying enzyme involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. It catalyzes the conjugation of reduced glutathione to a wide range of exogenous and endogenous hydrophobic electrophiles, with high efficiency for 4-hydroxynonenal (4-HNE). GSTA4 is expressed in various tissues, including liver, kidney, and brain, and plays a crucial role in protecting cells from oxidative stress. The enzyme is encoded by the GSTA4 gene located on chromosome 6 in humans. GSTA4 has been implicated in several diseases, including Parkinson's disease, Alzheimer's disease, and atherosclerosis. Decreased expression of GSTA4 has been observed in burn and trauma victims, while increased expression has been noted in colorectal cancer.