人 GSAP 抗体对
01AB04042
Gamma-secretase-activating protein (GSAP), also known as PION, is a protein that enhances the production of amyloid-beta (Aβ) by facilitating the interaction between the γ-secretase complex and its substrate, the amyloid precursor protein (APP). Characterized by its ability to bind both γ-secretase and APP, GSAP increases the efficiency of Aβ generation, which is a key factor in the pathogenesis of Alzheimer's disease (AD). Dysregulation of GSAP has been linked to neurodegenerative diseases, particularly AD, where elevated levels of Aβ contribute to plaque formation and neuronal toxicity. Additionally, GSAP may play a role in other conditions such as pontocerebellar hypoplasia type 3, highlighting its involvement in neurodevelopmental processes.
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技术参数
- 靶点基因名
- GSAP
- 基因别名
- PION
- 蛋白别名
- gamma-secretase activating protein; GSAP
- UniProt
- A4D1B5
- 物种
- Human
产品详情
- 靶点名称
- GSAP
- 蛋白名称
- gamma-secretase activating protein
- 蛋白别名
- Gamma-secretase-activating protein; GSAP; Protein pigeon homolog) [Cleaved into: Gamma-secretase-activating protein 16 kDa C-terminal form; GSAP-16K]
- 靶点基因名
- GSAP
- 基因别名
- PION
- UniProt
- A4D1B5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Gamma-secretase-activating protein (GSAP), also known as PION, is a protein that enhances the production of amyloid-beta (Aβ) by facilitating the interaction between the γ-secretase complex and its substrate, the amyloid precursor protein (APP). Characterized by its ability to bind both γ-secretase and APP, GSAP increases the efficiency of Aβ generation, which is a key factor in the pathogenesis of Alzheimer's disease (AD). Dysregulation of GSAP has been linked to neurodegenerative diseases, particularly AD, where elevated levels of Aβ contribute to plaque formation and neuronal toxicity. Additionally, GSAP may play a role in other conditions such as pontocerebellar hypoplasia type 3, highlighting its involvement in neurodevelopmental processes.