人 GRP94 抗体对
01AB00519
Heat shock protein 90 beta family member 1 (HSP90B1), also known as endoplasmic reticulum chaperone Grp94, is a molecular chaperone that plays a crucial role in protein folding and cell surface export of newly synthesized proteins, particularly Toll-like receptors and integrins. It is located in the endoplasmic reticulum and is essential for proper protein folding and preventing protein misfolding and aggregation. This protein is essential for both innate and adaptive immunity, and its dysfunction has been linked to various diseases, including cancer and glaucoma. HSP90B1 has been investigated as a target for cancer immunotherapy, with tumor-derived forms undergoing clinical trials as potential therapeutic agents.
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技术参数
- 靶点基因名
- HSP90B1
- 基因别名
- GRP94; HSPC4; TRA1
- 蛋白别名
- heat shock protein 90 beta family member 1; GRP94
- UniProt
- P14625
- 物种
- Human
产品详情
- 靶点名称
- GRP94
- 蛋白名称
- heat shock protein 90 beta family member 1
- 蛋白别名
- Endoplasmin; 94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1; Tumor rejection antigen 1; gp96 homolog
- 靶点基因名
- HSP90B1
- 基因别名
- GRP94; HSPC4; TRA1
- UniProt
- P14625
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Heat shock protein 90 beta family member 1 (HSP90B1), also known as endoplasmic reticulum chaperone Grp94, is a molecular chaperone that plays a crucial role in protein folding and cell surface export of newly synthesized proteins, particularly Toll-like receptors and integrins. It is located in the endoplasmic reticulum and is essential for proper protein folding and preventing protein misfolding and aggregation. This protein is essential for both innate and adaptive immunity, and its dysfunction has been linked to various diseases, including cancer and glaucoma. HSP90B1 has been investigated as a target for cancer immunotherapy, with tumor-derived forms undergoing clinical trials as potential therapeutic agents.