人 GRASP65 抗体对
01AB00510
Golgi reassembly-stacking protein 1 (GORASP1), also known as GRASP65, is a crucial peripheral membrane protein encoded by the GORASP1 gene in humans. It plays a significant role in maintaining the structure of the Golgi apparatus by facilitating the stacking of Golgi cisternae and linking them into larger ribbons through its interactions with other proteins, such as GM130 and p115. GORASP1 is essential for the proper functioning of the Golgi complex, particularly in protein sorting and modification processes. Additionally, it is implicated in apoptosis, as it serves as a substrate for caspase-3, leading to Golgi fragmentation during cell death. Dysregulation or mutations in GORASP1 have been associated with various diseases, including congenital disorders of glycosylation and immunodeficiencies.
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技术参数
- 靶点基因名
- GORASP1
- 基因别名
- GOLPH5; GRASP65
- 蛋白别名
- golgi reassembly stacking protein 1; GRASP65
- UniProt
- Q9BQQ3
- 物种
- Human
产品详情
- 靶点名称
- GRASP65
- 蛋白名称
- golgi reassembly stacking protein 1
- 蛋白别名
- Golgi reassembly-stacking protein 1; Golgi peripheral membrane protein p65; Golgi phosphoprotein 5; GOLPH5; Golgi reassembly-stacking protein of 65 kDa; GRASP65
- 靶点基因名
- GORASP1
- 基因别名
- GOLPH5; GRASP65
- UniProt
- Q9BQQ3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Golgi reassembly-stacking protein 1 (GORASP1), also known as GRASP65, is a crucial peripheral membrane protein encoded by the GORASP1 gene in humans. It plays a significant role in maintaining the structure of the Golgi apparatus by facilitating the stacking of Golgi cisternae and linking them into larger ribbons through its interactions with other proteins, such as GM130 and p115. GORASP1 is essential for the proper functioning of the Golgi complex, particularly in protein sorting and modification processes. Additionally, it is implicated in apoptosis, as it serves as a substrate for caspase-3, leading to Golgi fragmentation during cell death. Dysregulation or mutations in GORASP1 have been associated with various diseases, including congenital disorders of glycosylation and immunodeficiencies.