抗人 Granzyme B 抗体对
01AB00676
Granzyme B (GZMB) is a serine protease encoded by the GZMB gene on chromosome 14q.11.2, playing a crucial role in the immune response by inducing apoptosis in virus-infected and tumor cells. It is secreted by cytotoxic lymphocytes and enters target cells via the pore-forming protein perforin, activating caspases that trigger apoptotic pathways. GZMB has a unique substrate specificity, cleaving proteins involved in various cellular processes, including inflammation and extracellular matrix remodeling. Elevated levels of GZMB have been associated with several diseases, including cancer, where it can overcome resistance to conventional therapies. Its ability to induce apoptosis makes it a potential therapeutic agent in immunotherapy for malignancies. Additionally, GZMB is implicated in inflammatory responses and tissue repair, highlighting its dual role in both promoting cell death and facilitating recovery from injury.
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技术参数
- 靶点基因名
- GZMB
- 基因别名
- CGL1; CSPB; CTLA1; GRB
- 蛋白别名
- granzyme B; Granzyme B
- UniProt
- P10144
- 物种
- Human
产品详情
- 靶点名称
- Granzyme B
- 蛋白名称
- granzyme B
- 蛋白别名
- Granzyme B; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E
- 靶点基因名
- GZMB
- 基因别名
- CGL1; CSPB; CTLA1; GRB
- UniProt
- P10144
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Granzyme B (GZMB) is a serine protease encoded by the GZMB gene on chromosome 14q.11.2, playing a crucial role in the immune response by inducing apoptosis in virus-infected and tumor cells. It is secreted by cytotoxic lymphocytes and enters target cells via the pore-forming protein perforin, activating caspases that trigger apoptotic pathways. GZMB has a unique substrate specificity, cleaving proteins involved in various cellular processes, including inflammation and extracellular matrix remodeling. Elevated levels of GZMB have been associated with several diseases, including cancer, where it can overcome resistance to conventional therapies. Its ability to induce apoptosis makes it a potential therapeutic agent in immunotherapy for malignancies. Additionally, GZMB is implicated in inflammatory responses and tissue repair, highlighting its dual role in both promoting cell death and facilitating recovery from injury.