人 GPS2 抗体对
01AB03125
G protein pathway suppressor 2 (GPS2) is a ubiquitously expressed transcriptional corepressor and signaling regulator. As a component of the NCoR/SMRT nuclear receptor complex, it inhibits ubiquitin-conjugating enzymes to modulate MAPK, NF-kappaB, and PI3K/AKT pathways, playing key roles in inflammation, lipid metabolism, and mitochondrial homeostasis. In cancer, GPS2 often functions as a tumor suppressor; its downregulation in breast and gastric cancers drives unconstrained signaling activation, promoting metastasis and poor survival. Conversely, it may act as an oncogenic factor in liposarcoma and obesity-associated metabolic disorders.
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技术参数
- 靶点基因名
- GPS2
- 蛋白别名
- G protein pathway suppressor 2; GPS2
- UniProt
- Q13227
- 物种
- Human
产品详情
- 靶点名称
- GPS2
- 蛋白名称
- G protein pathway suppressor 2
- 蛋白别名
- G protein pathway suppressor 2; GPS-2
- 靶点基因名
- GPS2
- UniProt
- Q13227
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
G protein pathway suppressor 2 (GPS2) is a ubiquitously expressed transcriptional corepressor and signaling regulator. As a component of the NCoR/SMRT nuclear receptor complex, it inhibits ubiquitin-conjugating enzymes to modulate MAPK, NF-kappaB, and PI3K/AKT pathways, playing key roles in inflammation, lipid metabolism, and mitochondrial homeostasis. In cancer, GPS2 often functions as a tumor suppressor; its downregulation in breast and gastric cancers drives unconstrained signaling activation, promoting metastasis and poor survival. Conversely, it may act as an oncogenic factor in liposarcoma and obesity-associated metabolic disorders.