人 GPKOW 抗体对
01AB02718
G-patch domain and KOW motifs (GPKOW) is a conserved, nuclear RNA-binding protein of approximately 55 kDa that contains one G-patch domain and two KOW motifs, both of which are implicated in nucleic acid and protein interactions essential for pre-mRNA splicing, particularly as a component of the minor spliceosome involved in U12-type intron processing. The G-patch domain, about 48-50 amino acids in length, is rich in conserved glycines and is thought to facilitate binding to single-stranded RNA and DNA, while the KOW motifs, each around 27 amino acids, form β strands that provide non-overlapping binding sites for nucleic acids and proteins, structurally resembling Tudor domains. GPKOW function is regulated by protein kinase A (PKA), with evidence suggesting that PKA-mediated phosphorylation modulates its RNA-binding activity and potentially its role in post-transcriptional mRNA processing. Upregulation of GPKOW has been observed in some disease contexts, and its essentiality in cancer cell lines suggests a possible role in tumorigenesis or cell survival pathways.
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技术参数
- 靶点基因名
- GPKOW
- 基因别名
- GPATC5; GPATCH5; T54
- 蛋白别名
- G-patch domain and KOW motifs; GPKOW
- UniProt
- Q92917
- 物种
- Human
产品详情
- 靶点名称
- GPKOW
- 蛋白名称
- G-patch domain and KOW motifs
- 蛋白别名
- G-patch domain and KOW motifs-containing protein; G-patch domain-containing protein 5; Protein MOS2 homolog; Protein T54
- 靶点基因名
- GPKOW
- 基因别名
- GPATC5; GPATCH5; T54
- UniProt
- Q92917
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
G-patch domain and KOW motifs (GPKOW) is a conserved, nuclear RNA-binding protein of approximately 55 kDa that contains one G-patch domain and two KOW motifs, both of which are implicated in nucleic acid and protein interactions essential for pre-mRNA splicing, particularly as a component of the minor spliceosome involved in U12-type intron processing. The G-patch domain, about 48-50 amino acids in length, is rich in conserved glycines and is thought to facilitate binding to single-stranded RNA and DNA, while the KOW motifs, each around 27 amino acids, form β strands that provide non-overlapping binding sites for nucleic acids and proteins, structurally resembling Tudor domains. GPKOW function is regulated by protein kinase A (PKA), with evidence suggesting that PKA-mediated phosphorylation modulates its RNA-binding activity and potentially its role in post-transcriptional mRNA processing. Upregulation of GPKOW has been observed in some disease contexts, and its essentiality in cancer cell lines suggests a possible role in tumorigenesis or cell survival pathways.