抗人 GPC5 抗体对
01AB01967
Glypican 5 (GPC5) is a cell-surface heparan sulfate proteoglycan attached to the plasma membrane via a GPI anchor. It functions as a critical co-receptor that modulates major signaling pathways, most notably the Hedgehog (Hh) and fibroblast growth factor (FGF) pathways. Through its highly sulfated glycosaminoglycan chains, GPC5 binds both Sonic Hedgehog and its receptor Patched-1 at the primary cilia, thereby enhancing Hh-mediated cell proliferation and migration. In clinical contexts, GPC5 is frequently overexpressed in rhabdomyosarcoma, where it acts as a driver of tumor growth. Its role in developmental signaling and its association with various cancers underscore its importance in both normal morphogenesis and oncogenic transformation.
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技术参数
- 靶点基因名
- GPC5
- 蛋白别名
- glypican 5; GPC5
- UniProt
- P78333
- 物种
- Human
产品详情
- 靶点名称
- GPC5
- 蛋白名称
- glypican 5
- 蛋白别名
- Glypican-5 [Cleaved into: Secreted glypican-5]
- 靶点基因名
- GPC5
- UniProt
- P78333
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Glypican 5 (GPC5) is a cell-surface heparan sulfate proteoglycan attached to the plasma membrane via a GPI anchor. It functions as a critical co-receptor that modulates major signaling pathways, most notably the Hedgehog (Hh) and fibroblast growth factor (FGF) pathways. Through its highly sulfated glycosaminoglycan chains, GPC5 binds both Sonic Hedgehog and its receptor Patched-1 at the primary cilia, thereby enhancing Hh-mediated cell proliferation and migration. In clinical contexts, GPC5 is frequently overexpressed in rhabdomyosarcoma, where it acts as a driver of tumor growth. Its role in developmental signaling and its association with various cancers underscore its importance in both normal morphogenesis and oncogenic transformation.