人 GPA33 抗体对
01AB02196
Glycoprotein A33 (GPA33) is a type I transmembrane glycoprotein characterized by two extracellular immunoglobulin-like domains, a single transmembrane segment, and a cytoplasmic tail. It functions primarily in cell-cell recognition and signaling within the intestinal epithelium. GPA33 is highly distinguished by its restricted expression pattern; it is a selective cell surface antigen found in over 95% of human colorectal cancers while remaining largely absent from most other normal tissues and tumor types. This high specificity makes GPA33 a prominent target for antibody-based diagnostic imaging and therapeutic interventions in oncology. Although its precise functional links to other diseases remain under investigation, its established role as a colorectal cancer-associated antigen is central to its clinical and research relevance.
| 规格 | 起售价 |
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技术参数
- 靶点基因名
- GPA33
- 蛋白别名
- glycoprotein A33; GPA33
- UniProt
- Q99795
- 物种
- Human
产品详情
- 靶点名称
- GPA33
- 蛋白名称
- glycoprotein A33
- 蛋白别名
- Cell surface A33 antigen; Glycoprotein A33
- 靶点基因名
- GPA33
- UniProt
- Q99795
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Glycoprotein A33 (GPA33) is a type I transmembrane glycoprotein characterized by two extracellular immunoglobulin-like domains, a single transmembrane segment, and a cytoplasmic tail. It functions primarily in cell-cell recognition and signaling within the intestinal epithelium. GPA33 is highly distinguished by its restricted expression pattern; it is a selective cell surface antigen found in over 95% of human colorectal cancers while remaining largely absent from most other normal tissues and tumor types. This high specificity makes GPA33 a prominent target for antibody-based diagnostic imaging and therapeutic interventions in oncology. Although its precise functional links to other diseases remain under investigation, its established role as a colorectal cancer-associated antigen is central to its clinical and research relevance.