人 GP5 抗体对
01AB00833
Glycoprotein V platelet (GP5) is a crucial component of the Ib-V-IX complex on platelet surfaces, functioning as a receptor for von Willebrand factor (VWF) and mediating platelet adhesion to injured vascular surfaces in arterial circulation. This 82 kDa membrane-associated protein is part of a heterodimer with alpha (GP1BA) and beta (GP1BB) chains, linked by disulfide bonds. GP5 plays a vital role in hemostasis and platelet activation, with its collagen-binding activity contributing to these processes. Mutations in GP5, along with GP1BA, GP1BB, and GP9, have been associated with Bernard-Soulier syndrome, a rare bleeding disorder characterized by abnormal platelet function. Additionally, recent research suggests that GP5 may be involved in regulating epithelial-mesenchymal transition in breast cancer via the PI3K/AKT signaling pathway.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- GP5
- 蛋白别名
- glycoprotein V platelet; GP5
- UniProt
- P40197
- 物种
- Human
产品详情
- 靶点名称
- GP5
- 蛋白名称
- glycoprotein V platelet
- 蛋白别名
- Platelet glycoprotein V; GPV; Glycoprotein 5; CD antigen CD42d
- 靶点基因名
- GP5
- UniProt
- P40197
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Glycoprotein V platelet (GP5) is a crucial component of the Ib-V-IX complex on platelet surfaces, functioning as a receptor for von Willebrand factor (VWF) and mediating platelet adhesion to injured vascular surfaces in arterial circulation. This 82 kDa membrane-associated protein is part of a heterodimer with alpha (GP1BA) and beta (GP1BB) chains, linked by disulfide bonds. GP5 plays a vital role in hemostasis and platelet activation, with its collagen-binding activity contributing to these processes. Mutations in GP5, along with GP1BA, GP1BB, and GP9, have been associated with Bernard-Soulier syndrome, a rare bleeding disorder characterized by abnormal platelet function. Additionally, recent research suggests that GP5 may be involved in regulating epithelial-mesenchymal transition in breast cancer via the PI3K/AKT signaling pathway.