人 GOT2 抗体对
01AB03451
Glutamic-oxaloacetic transaminase 2 (GOT2) is a mitochondrial, pyridoxal phosphate-dependent enzyme that functions as a homodimer to facilitate key steps in amino acid metabolism, the urea cycle, and the tricarboxylic acid cycle. It is a vital component of the malate-aspartate shuttle, which is responsible for transferring reducing equivalents across the mitochondrial membrane to maintain NAD(H) redox balance and support cellular energy production. Additionally, GOT2 catalyzes the transamination of kynurenine to kynurenic acid in the brain and assists in the cellular uptake of long-chain fatty acids. Clinically, GOT2 is highly relevant in oncology, particularly in breast and pancreatic cancers, where its role in the malate-aspartate shuttle supports the metabolic demands of rapid cell proliferation. Furthermore, mutations in the GOT2 gene are established causes of developmental and epileptic encephalopathy 82, a severe early-onset neurological disorder characterized by seizures and significant developmental dysfunction.
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技术参数
- 靶点基因名
- GOT2
- 基因别名
- KYAT4
- 蛋白别名
- glutamic-oxaloacetic transaminase 2; GOT2
- UniProt
- P00505
- 物种
- Human
产品详情
- 靶点名称
- GOT2
- 蛋白名称
- glutamic-oxaloacetic transaminase 2
- 蛋白别名
- Aspartate aminotransferase; mitochondrial; mAspAT; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A
- 靶点基因名
- GOT2
- 基因别名
- KYAT4
- UniProt
- P00505
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Glutamic-oxaloacetic transaminase 2 (GOT2) is a mitochondrial, pyridoxal phosphate-dependent enzyme that functions as a homodimer to facilitate key steps in amino acid metabolism, the urea cycle, and the tricarboxylic acid cycle. It is a vital component of the malate-aspartate shuttle, which is responsible for transferring reducing equivalents across the mitochondrial membrane to maintain NAD(H) redox balance and support cellular energy production. Additionally, GOT2 catalyzes the transamination of kynurenine to kynurenic acid in the brain and assists in the cellular uptake of long-chain fatty acids. Clinically, GOT2 is highly relevant in oncology, particularly in breast and pancreatic cancers, where its role in the malate-aspartate shuttle supports the metabolic demands of rapid cell proliferation. Furthermore, mutations in the GOT2 gene are established causes of developmental and epileptic encephalopathy 82, a severe early-onset neurological disorder characterized by seizures and significant developmental dysfunction.