人 GNG11 抗体对
01AB03119
G protein subunit gamma 11 (GNG11) encodes a lipid-anchored component of heterotrimeric G protein complexes. Localizing to the plasma membrane, it forms functional dimers with beta subunits to facilitate GTPase activity and signal transduction for pathways such as thromboxane signaling. GNG11 is essential for proper G-protein coupling and downstream effector activation. Clinically, reduced GNG11 expression is associated with splenic marginal zone lymphoma, suggesting a tumor-suppressive function. The gene is also linked to cone-rod dystrophy 10, a retinal degenerative disorder, implicating it in the maintenance of photoreceptor physiology.
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技术参数
- 靶点基因名
- GNG11
- 基因别名
- GNGT11
- 蛋白别名
- G protein subunit gamma 11; GNG11
- UniProt
- P61952
- 物种
- Human
产品详情
- 靶点名称
- GNG11
- 蛋白名称
- G protein subunit gamma 11
- 蛋白别名
- Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
- 靶点基因名
- GNG11
- 基因别名
- GNGT11
- UniProt
- P61952
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
G protein subunit gamma 11 (GNG11) encodes a lipid-anchored component of heterotrimeric G protein complexes. Localizing to the plasma membrane, it forms functional dimers with beta subunits to facilitate GTPase activity and signal transduction for pathways such as thromboxane signaling. GNG11 is essential for proper G-protein coupling and downstream effector activation. Clinically, reduced GNG11 expression is associated with splenic marginal zone lymphoma, suggesting a tumor-suppressive function. The gene is also linked to cone-rod dystrophy 10, a retinal degenerative disorder, implicating it in the maintenance of photoreceptor physiology.