人 GM130 抗体对
01AB00253
Golgin A2 (GOLGA2), also known as GM130, is a critical protein encoded by the GOLGA2 gene in humans, located on chromosome 9. It is localized to the Golgi apparatus, a complex organelle involved in the glycosylation and transport of proteins and lipids in the secretory pathway. It acts as a peripheral membrane component of the cis-Golgi stack, maintaining the structure of the Golgi apparatus by acting as a membrane skeleton. Golgin A2 is a member of the golgin family and has been postulated to play roles in the stacking of Golgi cisternae and in the regulation of Golgi function. Bi-allelic loss of function variants in GOLGA2 have been associated with a complex neurological phenotype, as reported in studies of affected families.
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技术参数
- 靶点基因名
- GOLGA2
- 蛋白别名
- golgin A2; GM130
- UniProt
- Q08379
- 物种
- Human
产品详情
- 靶点名称
- GM130
- 蛋白名称
- golgin A2
- 蛋白别名
- Golgin subfamily A member 2; 130 kDa cis-Golgi matrix protein; GM130; GM130 autoantigen; Golgin-95
- 靶点基因名
- GOLGA2
- UniProt
- Q08379
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Golgin A2 (GOLGA2), also known as GM130, is a critical protein encoded by the GOLGA2 gene in humans, located on chromosome 9. It is localized to the Golgi apparatus, a complex organelle involved in the glycosylation and transport of proteins and lipids in the secretory pathway. It acts as a peripheral membrane component of the cis-Golgi stack, maintaining the structure of the Golgi apparatus by acting as a membrane skeleton. Golgin A2 is a member of the golgin family and has been postulated to play roles in the stacking of Golgi cisternae and in the regulation of Golgi function. Bi-allelic loss of function variants in GOLGA2 have been associated with a complex neurological phenotype, as reported in studies of affected families.