人 GM-CSF 抗体对
01AB02117
CSF2, also known as granulocyte-macrophage colony-stimulating factor (GM-CSF), is a cytokine that functions as a white blood cell growth factor. It stimulates the stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. GM-CSF has been implicated in the pathogenesis of various autoimmune and inflammatory diseases. It plays a central role in regulating inflammatory responses, including promoting the production of pro-inflammatory cytokines and activating myeloid cells like macrophages and dendritic cells. Elevated GM-CSF levels have been observed in conditions like rheumatoid arthritis, multiple sclerosis, asthma, and COVID-19. Blocking GM-CSF or its receptor has shown therapeutic potential in preclinical and clinical studies for these inflammatory disorders. Overall, GM-CSF appears to be a key mediator linking T cell responses to myeloid cell-driven tissue damage in chronic inflammatory diseases.
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技术参数
- 靶点基因名
- CSF2
- 基因别名
- GMCSF
- 蛋白别名
- colony stimulating factor 2; GM-CSF
- UniProt
- P04141
- 物种
- Human
产品详情
- 靶点名称
- GM-CSF
- 蛋白名称
- colony stimulating factor 2
- 蛋白别名
- Granulocyte-macrophage colony-stimulating factor; GM-CSF; Colony-stimulating factor; CSF; Molgramostin; Sargramostim
- 靶点基因名
- CSF2
- 基因别名
- GMCSF
- UniProt
- P04141
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CSF2, also known as granulocyte-macrophage colony-stimulating factor (GM-CSF), is a cytokine that functions as a white blood cell growth factor. It stimulates the stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. GM-CSF has been implicated in the pathogenesis of various autoimmune and inflammatory diseases. It plays a central role in regulating inflammatory responses, including promoting the production of pro-inflammatory cytokines and activating myeloid cells like macrophages and dendritic cells. Elevated GM-CSF levels have been observed in conditions like rheumatoid arthritis, multiple sclerosis, asthma, and COVID-19. Blocking GM-CSF or its receptor has shown therapeutic potential in preclinical and clinical studies for these inflammatory disorders. Overall, GM-CSF appears to be a key mediator linking T cell responses to myeloid cell-driven tissue damage in chronic inflammatory diseases.