人 Glycodelin 抗体对
01AB01785
Progestagen associated endometrial protein (Glycodelin) is a secreted dimeric glycoprotein of the lipocalin family that plays a pivotal role in human reproduction and immunomodulation. Expressed in the endometrium under progesterone influence, it exists as several glycoforms—including glycodelin-A, -F, -S, and -C—whose specific glycosylation patterns dictate their biological activities, such as inhibiting sperm-egg binding and regulating trophoblast invasion. Glycodelin-A is particularly noted for its immunosuppressive and pro-apoptotic effects on immune cells, which are essential for maintaining fetomaternal tolerance. Clinically, altered glycodelin expression is associated with endometriosis and hormone-related cancers. In endometrial carcinoma, it is proposed to act as a tumor suppressor by promoting a more differentiated, less malignant cellular phenotype.
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技术参数
- 靶点基因名
- PAEP
- 蛋白别名
- progestagen associated endometrial protein; Glycodelin
- UniProt
- P09466
- 物种
- Human
产品详情
- 靶点名称
- Glycodelin
- 蛋白名称
- progestagen associated endometrial protein
- 蛋白别名
- Glycodelin; GD; Placental protein 14; PP14; Pregnancy-associated endometrial alpha-2 globulin; PAEG; PEG; Progestagen-associated endometrial protein; Progesterone-associated endometrial protein; Zona-binding inhibitory factor-1; ZIF-1
- 靶点基因名
- PAEP
- UniProt
- P09466
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Progestagen associated endometrial protein (Glycodelin) is a secreted dimeric glycoprotein of the lipocalin family that plays a pivotal role in human reproduction and immunomodulation. Expressed in the endometrium under progesterone influence, it exists as several glycoforms—including glycodelin-A, -F, -S, and -C—whose specific glycosylation patterns dictate their biological activities, such as inhibiting sperm-egg binding and regulating trophoblast invasion. Glycodelin-A is particularly noted for its immunosuppressive and pro-apoptotic effects on immune cells, which are essential for maintaining fetomaternal tolerance. Clinically, altered glycodelin expression is associated with endometriosis and hormone-related cancers. In endometrial carcinoma, it is proposed to act as a tumor suppressor by promoting a more differentiated, less malignant cellular phenotype.