人 Glutathione Peroxidase 4 抗体对
01AB00516
Glutathione peroxidase 4 (GPX4) is a selenium-dependent enzyme that plays a crucial role in protecting cells against lipid peroxidation by reducing phospholipid hydroperoxides in cell membranes. GPX4 is unique among glutathione peroxidases due to its high affinity for large, membrane-bound substrates and its ability to directly reduce lipid hydroperoxides inside biological membranes. The enzyme is essential for cell survival and development, with its inactivation leading to ferroptotic cell death and accumulation of lipid peroxides. Mutations in GPX4 have been associated with diseases such as spondylometaphyseal dysplasia and Sedaghatian-type spinal metaphyseal dysplasia. Additionally, GPX4 has been implicated in various pathophysiological processes including inflammation, neurodegeneration, and cancer.
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技术参数
- 靶点基因名
- GPX4
- 蛋白别名
- glutathione peroxidase 4; Glutathione Peroxidase 4
- UniProt
- P36969
- 物种
- Human
产品详情
- 靶点名称
- Glutathione Peroxidase 4
- 蛋白名称
- glutathione peroxidase 4
- 蛋白别名
- Phospholipid hydroperoxide glutathione peroxidase; PHGPx; Glutathione peroxidase 4; GPx-4; GSHPx-4
- 靶点基因名
- GPX4
- UniProt
- P36969
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Glutathione peroxidase 4 (GPX4) is a selenium-dependent enzyme that plays a crucial role in protecting cells against lipid peroxidation by reducing phospholipid hydroperoxides in cell membranes. GPX4 is unique among glutathione peroxidases due to its high affinity for large, membrane-bound substrates and its ability to directly reduce lipid hydroperoxides inside biological membranes. The enzyme is essential for cell survival and development, with its inactivation leading to ferroptotic cell death and accumulation of lipid peroxides. Mutations in GPX4 have been associated with diseases such as spondylometaphyseal dysplasia and Sedaghatian-type spinal metaphyseal dysplasia. Additionally, GPX4 has been implicated in various pathophysiological processes including inflammation, neurodegeneration, and cancer.