人 GLI2 抗体对
01AB00252
GLI family zinc finger 2 (GLI2) is a transcription factor belonging to the GLI family of zinc finger proteins. It functions as a mediator of Sonic hedgehog (Shh) signaling and plays crucial roles in embryonic development and cell fate determination. GLI2 contains DNA-binding zinc finger motifs, a repressor domain at the N-terminus, and an activator domain at the C-terminus. It can act as both a transcriptional activator and repressor, with its activity regulated through post-translational modifications and protein-protein interactions. GLI2 localizes to the cytoplasm and nucleus, where it regulates target gene expression involved in proliferation, survival, and differentiation. Mutations in GLI2 are associated with holoprosencephaly, a disorder of forebrain development, as well as pituitary anomalies and polydactyly. GLI2 dysregulation has also been implicated in various cancers, including medulloblastoma and basal cell carcinoma.
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技术参数
- 靶点基因名
- GLI2
- 基因别名
- THP
- 蛋白别名
- GLI family zinc finger 2; GLI2
- UniProt
- P10070
- 物种
- Human
产品详情
- 靶点名称
- GLI2
- 蛋白名称
- GLI family zinc finger 2
- 蛋白别名
- Zinc finger protein GLI2; GLI family zinc finger protein 2; Tax helper protein
- 靶点基因名
- GLI2
- 基因别名
- THP
- UniProt
- P10070
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
GLI family zinc finger 2 (GLI2) is a transcription factor belonging to the GLI family of zinc finger proteins. It functions as a mediator of Sonic hedgehog (Shh) signaling and plays crucial roles in embryonic development and cell fate determination. GLI2 contains DNA-binding zinc finger motifs, a repressor domain at the N-terminus, and an activator domain at the C-terminus. It can act as both a transcriptional activator and repressor, with its activity regulated through post-translational modifications and protein-protein interactions. GLI2 localizes to the cytoplasm and nucleus, where it regulates target gene expression involved in proliferation, survival, and differentiation. Mutations in GLI2 are associated with holoprosencephaly, a disorder of forebrain development, as well as pituitary anomalies and polydactyly. GLI2 dysregulation has also been implicated in various cancers, including medulloblastoma and basal cell carcinoma.