抗人 GKN1 抗体对
01AB01146
Gastrokine 1 (GKN1) is a 18-20 kDa stomach-specific protein highly expressed in normal gastric mucosa but downregulated or absent in gastric cancer. It contains a BRICHOS domain and plays a crucial role in maintaining gastric mucosal integrity and epithelial homeostasis. GKN1 exhibits mitogenic activity, interacts with other proteins, and has anti-amyloidogenic properties. It is secreted and co-localizes with actin in gastric epithelial cells. GKN1 expression is reduced in H. pylori-positive chronic gastritis and gastric cancer, suggesting its potential as a tumor suppressor. The protein's downregulation occurs throughout the progressive stages of neoplastic transformation, from chronic gastritis to gastric cancer. GKN1 overexpression in gastric cancer cell lines activates Fas receptor expression and increases apoptosis, while recombinant GKN1 treatment reduces proliferation in gastric cancer cells.
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技术参数
- 靶点基因名
- GKN1
- 基因别名
- AMP18; CA11
- 蛋白别名
- gastrokine 1; GKN1
- UniProt
- Q9NS71
- 物种
- Human
产品详情
- 靶点名称
- GKN1
- 蛋白名称
- gastrokine 1
- 蛋白别名
- Gastrokine-1; 18 kDa antrum mucosa protein; AMP-18; Protein CA11
- 靶点基因名
- GKN1
- 基因别名
- AMP18; CA11
- UniProt
- Q9NS71
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Gastrokine 1 (GKN1) is a 18-20 kDa stomach-specific protein highly expressed in normal gastric mucosa but downregulated or absent in gastric cancer. It contains a BRICHOS domain and plays a crucial role in maintaining gastric mucosal integrity and epithelial homeostasis. GKN1 exhibits mitogenic activity, interacts with other proteins, and has anti-amyloidogenic properties. It is secreted and co-localizes with actin in gastric epithelial cells. GKN1 expression is reduced in H. pylori-positive chronic gastritis and gastric cancer, suggesting its potential as a tumor suppressor. The protein's downregulation occurs throughout the progressive stages of neoplastic transformation, from chronic gastritis to gastric cancer. GKN1 overexpression in gastric cancer cell lines activates Fas receptor expression and increases apoptosis, while recombinant GKN1 treatment reduces proliferation in gastric cancer cells.