抗人 GFRA3 抗体对
01AB01143
GDNF family receptor alpha 3 (GFRA3) is a glycosylphosphatidylinositol (GPI)-anchored cell surface receptor and a member of the GDNF receptor family, primarily functioning as a co-receptor for the neurotrophic factor artemin (ARTN) and forming a signaling complex with the RET tyrosine kinase receptor[. This receptor is integral to nervous system development, mediating ARTN-induced autophosphorylation and activation of RET, which in turn triggers downstream signaling pathways such as MAPK cascades and supports axon guidance and neuronal survival. Structurally, GFRA3 shares homology with other GDNF family receptors, featuring cysteine-rich domains that facilitate ligand binding and receptor activation. Disease associations for GFRA3 include breast duct papilloma, prostate cancer, and familial medullary thyroid carcinoma, suggesting its dysregulation may contribute to tumorigenesis or abnormal tissue growth, although its primary role remains in neurodevelopmental processes.
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技术参数
- 靶点基因名
- GFRA3
- 蛋白别名
- GDNF family receptor alpha 3; GFRA3
- UniProt
- O60609
- 物种
- Human
产品详情
- 靶点名称
- GFRA3
- 蛋白名称
- GDNF family receptor alpha 3
- 蛋白别名
- GDNF family receptor alpha-3; GDNF receptor alpha-3; GDNFR-alpha-3; GFR-alpha-3
- 靶点基因名
- GFRA3
- UniProt
- O60609
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
GDNF family receptor alpha 3 (GFRA3) is a glycosylphosphatidylinositol (GPI)-anchored cell surface receptor and a member of the GDNF receptor family, primarily functioning as a co-receptor for the neurotrophic factor artemin (ARTN) and forming a signaling complex with the RET tyrosine kinase receptor[. This receptor is integral to nervous system development, mediating ARTN-induced autophosphorylation and activation of RET, which in turn triggers downstream signaling pathways such as MAPK cascades and supports axon guidance and neuronal survival. Structurally, GFRA3 shares homology with other GDNF family receptors, featuring cysteine-rich domains that facilitate ligand binding and receptor activation. Disease associations for GFRA3 include breast duct papilloma, prostate cancer, and familial medullary thyroid carcinoma, suggesting its dysregulation may contribute to tumorigenesis or abnormal tissue growth, although its primary role remains in neurodevelopmental processes.