人 GFRA2 抗体对
01AB01703
GDNF family receptor alpha 2 (GFRA2) is a glycosylphosphatidylinositol (GPI)-anchored cell-surface co-receptor that primarily binds the neurotrophic factor neurturin (NRTN). It also exhibits affinity for glial cell line-derived neurotrophic factor (GDNF). Upon ligand binding, GFRA2 forms a signaling complex with the RET tyrosine kinase receptor, activating downstream pathways such as MAPK to support the survival and differentiation of sympathetic and parasympathetic neurons. GFRA2 is predominantly expressed in the nervous system and is essential for maintaining enteric and retinal neuronal health. Clinically, GFRA2 is considered a candidate gene for RET-associated neurocristopathies, with established associations to Hirschsprung disease 1 and retinal degeneration, where impaired neurotrophic support leads to significant neuronal dysfunction.
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技术参数
- 靶点基因名
- GFRA2
- 基因别名
- GDNFRB; RETL2; TRNR2
- 蛋白别名
- GDNF family receptor alpha 2; GFRA2
- UniProt
- O00451
- 物种
- Human
产品详情
- 靶点名称
- GFRA2
- 蛋白名称
- GDNF family receptor alpha 2
- 蛋白别名
- GDNF family receptor alpha-2; GDNF receptor alpha-2; GDNFR-alpha-2; GFR-alpha-2; GDNF receptor beta; GDNFR-beta; Neurturin receptor alpha; NRTNR-alpha; NTNR-alpha; RET ligand 2; TGF-beta-related neurotrophic factor receptor 2
- 靶点基因名
- GFRA2
- 基因别名
- GDNFRB; RETL2; TRNR2
- UniProt
- O00451
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
GDNF family receptor alpha 2 (GFRA2) is a glycosylphosphatidylinositol (GPI)-anchored cell-surface co-receptor that primarily binds the neurotrophic factor neurturin (NRTN). It also exhibits affinity for glial cell line-derived neurotrophic factor (GDNF). Upon ligand binding, GFRA2 forms a signaling complex with the RET tyrosine kinase receptor, activating downstream pathways such as MAPK to support the survival and differentiation of sympathetic and parasympathetic neurons. GFRA2 is predominantly expressed in the nervous system and is essential for maintaining enteric and retinal neuronal health. Clinically, GFRA2 is considered a candidate gene for RET-associated neurocristopathies, with established associations to Hirschsprung disease 1 and retinal degeneration, where impaired neurotrophic support leads to significant neuronal dysfunction.