人 GFRA1 抗体对
01AB01699
GDNF family receptor alpha 1 (GFRA1) is a glycosylphosphatidylinositol (GPI)-anchored cell-surface co-receptor for glial cell line-derived neurotrophic factor (GDNF) and neurturin. It forms a signaling complex with the RET receptor tyrosine kinase to promote neuronal survival, differentiation, and morphogenesis within the central, peripheral, and enteric nervous systems. Structurally, GFRA1 is a cysteine-rich protein that assembles with GDNF in a 2:2 stoichiometry; it can also form higher-order decameric assemblies that mediate synaptic cell adhesion independently of RET. Clinically, GFRA1 is essential for proper organogenesis, and its dysfunction is implicated in congenital renal malformations, including renal hypodysplasia and bilateral renal agenesis. Additionally, due to its critical role in the development of the enteric nervous system, it is recognized as a candidate gene for Hirschsprung disease.
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技术参数
- 靶点基因名
- GFRA1
- 基因别名
- GDNFRA; RETL1; TRNR1
- 蛋白别名
- GDNF family receptor alpha 1; GFRA1
- UniProt
- P56159
- 物种
- Human
产品详情
- 靶点名称
- GFRA1
- 蛋白名称
- GDNF family receptor alpha 1
- 蛋白别名
- GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1
- 靶点基因名
- GFRA1
- 基因别名
- GDNFRA; RETL1; TRNR1
- UniProt
- P56159
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
GDNF family receptor alpha 1 (GFRA1) is a glycosylphosphatidylinositol (GPI)-anchored cell-surface co-receptor for glial cell line-derived neurotrophic factor (GDNF) and neurturin. It forms a signaling complex with the RET receptor tyrosine kinase to promote neuronal survival, differentiation, and morphogenesis within the central, peripheral, and enteric nervous systems. Structurally, GFRA1 is a cysteine-rich protein that assembles with GDNF in a 2:2 stoichiometry; it can also form higher-order decameric assemblies that mediate synaptic cell adhesion independently of RET. Clinically, GFRA1 is essential for proper organogenesis, and its dysfunction is implicated in congenital renal malformations, including renal hypodysplasia and bilateral renal agenesis. Additionally, due to its critical role in the development of the enteric nervous system, it is recognized as a candidate gene for Hirschsprung disease.