人 GEF-H1 抗体对
01AB02628
Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1) is a microtubule-associated factor that activates Rho family GTPases, primarily RhoA, by catalyzing GDP-GTP exchange. It is typically sequestered in an inactive state on microtubules and becomes activated upon microtubule depolymerization, thereby coupling microtubule dynamics to actin cytoskeleton remodeling and cell migration. GEF-H1 is involved in regulating cytokinesis, epithelial barrier function, and mechanotransduction. Pathologically, GEF-H1 is transcriptionally upregulated by oncogenic Ras/Raf/MEK/ERK signaling, supporting transformed growth in Ras-driven tumorigenesis. It also contributes to TNF-alpha-mediated barrier dysfunction and wound healing. In immune contexts, GEF-H1 modulates antigen presentation and tight-junction permeability, linking cytoskeletal regulation to inflammatory responses and barrier integrity.
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技术参数
- 靶点基因名
- ARHGEF2
- 基因别名
- KIAA0651; LFP40
- 蛋白别名
- Rho/Rac guanine nucleotide exchange factor 2; GEF-H1
- UniProt
- Q92974
- 物种
- Human
产品详情
- 靶点名称
- GEF-H1
- 蛋白名称
- Rho/Rac guanine nucleotide exchange factor 2
- 蛋白别名
- Rho guanine nucleotide exchange factor 2; Guanine nucleotide exchange factor H1; GEF-H1; Microtubule-regulated Rho-GEF; Proliferating cell nucleolar antigen p40
- 靶点基因名
- ARHGEF2
- 基因别名
- KIAA0651; LFP40
- UniProt
- Q92974
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1) is a microtubule-associated factor that activates Rho family GTPases, primarily RhoA, by catalyzing GDP-GTP exchange. It is typically sequestered in an inactive state on microtubules and becomes activated upon microtubule depolymerization, thereby coupling microtubule dynamics to actin cytoskeleton remodeling and cell migration. GEF-H1 is involved in regulating cytokinesis, epithelial barrier function, and mechanotransduction. Pathologically, GEF-H1 is transcriptionally upregulated by oncogenic Ras/Raf/MEK/ERK signaling, supporting transformed growth in Ras-driven tumorigenesis. It also contributes to TNF-alpha-mediated barrier dysfunction and wound healing. In immune contexts, GEF-H1 modulates antigen presentation and tight-junction permeability, linking cytoskeletal regulation to inflammatory responses and barrier integrity.