人 GDNF 抗体对
01AB04040
Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor that plays a critical role in the survival, development, and maintenance of neurons, particularly midbrain dopaminergic neurons. GDNF is initially synthesized as a precursor protein and undergoes proteolytic processing to form its active homodimeric structure, which consists of two 15 kDa monomers linked by disulfide bonds. It signals through the receptor tyrosine kinase RET, with the assistance of glycosylphosphatidylinositol-anchored co-receptors (GFRα1), leading to activation of intracellular pathways that promote neuronal health and survival. Dysregulation of GDNF has been implicated in several diseases, most notably Parkinson's disease, where reduced GDNF levels contribute to the degeneration of dopaminergic neurons. Additionally, mutations in the GDNF gene have been associated with Hirschsprung disease, a condition characterized by intestinal motility issues.
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技术参数
- 靶点基因名
- GDNF
- 蛋白别名
- glial cell derived neurotrophic factor; GDNF
- UniProt
- P39905
- 物种
- Human
产品详情
- 靶点名称
- GDNF
- 蛋白名称
- glial cell derived neurotrophic factor
- 蛋白别名
- Glial cell line-derived neurotrophic factor; hGDNF; Astrocyte-derived trophic factor; ATF
- 靶点基因名
- GDNF
- UniProt
- P39905
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor that plays a critical role in the survival, development, and maintenance of neurons, particularly midbrain dopaminergic neurons. GDNF is initially synthesized as a precursor protein and undergoes proteolytic processing to form its active homodimeric structure, which consists of two 15 kDa monomers linked by disulfide bonds. It signals through the receptor tyrosine kinase RET, with the assistance of glycosylphosphatidylinositol-anchored co-receptors (GFRα1), leading to activation of intracellular pathways that promote neuronal health and survival. Dysregulation of GDNF has been implicated in several diseases, most notably Parkinson's disease, where reduced GDNF levels contribute to the degeneration of dopaminergic neurons. Additionally, mutations in the GDNF gene have been associated with Hirschsprung disease, a condition characterized by intestinal motility issues.