人 GDF15 抗体对
01AB03744
Growth Differentiation Factor 15 (GDF15) is a stress-responsive cytokine belonging to the transforming growth factor-beta (TGF-β) superfamily. Synthesized as a 308-amino acid proprotein, it undergoes proteolytic cleavage to release a disulfide-linked homodimeric mature peptide (~25 kDa). GDF15 is widely expressed in tissues under pathological stress, including inflammation, hypoxia, or mitochondrial dysfunction. It signals through a receptor complex involving GDNF family receptor α-like (GFRAL) and RET tyrosine kinase, primarily in the brainstem, regulating energy homeostasis, appetite, and body weight. Elevated GDF15 levels are linked to diverse diseases, serving as a biomarker for conditions like cancer cachexia, cardiovascular diseases (e.g., heart failure, atherosclerosis), chronic kidney disease, and obesity-related metabolic disorders. In cancer, GDF15 promotes cachexia by suppressing appetite and inducing muscle wasting, while its role in obesity involves counteracting hyperphagia.
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技术参数
- 靶点基因名
- GDF15
- 基因别名
- MIC1; PDF; PLAB; PTGFB
- 蛋白别名
- growth differentiation factor 15; GDF15
- UniProt
- Q99988
- 物种
- Human
产品详情
- 靶点名称
- GDF15
- 蛋白名称
- growth differentiation factor 15
- 蛋白别名
- Growth/differentiation factor 15; GDF-15; Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor
- 靶点基因名
- GDF15
- 基因别名
- MIC1; PDF; PLAB; PTGFB
- UniProt
- Q99988
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Growth Differentiation Factor 15 (GDF15) is a stress-responsive cytokine belonging to the transforming growth factor-beta (TGF-β) superfamily. Synthesized as a 308-amino acid proprotein, it undergoes proteolytic cleavage to release a disulfide-linked homodimeric mature peptide (~25 kDa). GDF15 is widely expressed in tissues under pathological stress, including inflammation, hypoxia, or mitochondrial dysfunction. It signals through a receptor complex involving GDNF family receptor α-like (GFRAL) and RET tyrosine kinase, primarily in the brainstem, regulating energy homeostasis, appetite, and body weight. Elevated GDF15 levels are linked to diverse diseases, serving as a biomarker for conditions like cancer cachexia, cardiovascular diseases (e.g., heart failure, atherosclerosis), chronic kidney disease, and obesity-related metabolic disorders. In cancer, GDF15 promotes cachexia by suppressing appetite and inducing muscle wasting, while its role in obesity involves counteracting hyperphagia.