人 GCNT1 抗体对
01AB00827
Glucosaminyl (N-acetyl) transferase 1 (GCNT1) is a glycosyltransferase enzyme encoded by the GCNT1 gene in humans. It catalyzes the transfer of N-acetylglucosamine (GlcNAc) in beta1-6 linkage from UDP-GlcNAc to mucin-type core 1 O-glycans, forming core 2 O-glycans. GCNT1 plays a crucial role in the biosynthesis of branched O-glycans and is essential for the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures. The enzyme is localized to the Golgi apparatus and is expressed in various tissues, including the colon, pancreas, and prostate. GCNT1 is involved in the synthesis of sialyl Lewis x antigens on mucin-type glycoproteins. Overexpression of GCNT1 has been associated with the progression of several cancer types, particularly prostate cancer, where it is linked to higher levels of core 2 O-sLe(x) in PSA, PAP, and MUC1 proteins.
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技术参数
- 靶点基因名
- GCNT1
- 基因别名
- NACGT2
- 蛋白别名
- glucosaminyl (N-acetyl) transferase 1; GCNT1
- UniProt
- Q02742
- 物种
- Human
产品详情
- 靶点名称
- GCNT1
- 蛋白名称
- glucosaminyl (N-acetyl) transferase 1
- 蛋白别名
- Beta-1; 3-galactosyl-O-glycosyl-glycoprotein beta-1; 6-N-acetylglucosaminyltransferase; Core 2 beta-1; 6-N-acetylglucosaminyltransferase; C2GlcNAcT; Core 2-branching enzyme; Core2-GlcNAc-transferase; C2GNT; Core 2 GNT; Leukocyte type core 2 beta-1; 6-N-acetylglucosaminyltransferase; C2GnT-L
- 靶点基因名
- GCNT1
- 基因别名
- NACGT2
- UniProt
- Q02742
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Glucosaminyl (N-acetyl) transferase 1 (GCNT1) is a glycosyltransferase enzyme encoded by the GCNT1 gene in humans. It catalyzes the transfer of N-acetylglucosamine (GlcNAc) in beta1-6 linkage from UDP-GlcNAc to mucin-type core 1 O-glycans, forming core 2 O-glycans. GCNT1 plays a crucial role in the biosynthesis of branched O-glycans and is essential for the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures. The enzyme is localized to the Golgi apparatus and is expressed in various tissues, including the colon, pancreas, and prostate. GCNT1 is involved in the synthesis of sialyl Lewis x antigens on mucin-type glycoproteins. Overexpression of GCNT1 has been associated with the progression of several cancer types, particularly prostate cancer, where it is linked to higher levels of core 2 O-sLe(x) in PSA, PAP, and MUC1 proteins.