抗人 GCET1 抗体对
01AB00932
Serpin family A member 9 (SERPINA9) is a member of the serine protease inhibitor (serpin) family, encoded by the SERPINA9 gene. This secreted glycoprotein (45.9 kDa) contains a conserved serpin domain that facilitates its role in regulating proteolytic enzymes, particularly in the endoplasmic reticulum. SERPINA9 is primarily expressed in B-lymphocytes and lymphoid tissues, where it may inhibit proteases involved in antigen processing or apoptosis. Structural studies reveal its reactive center loop (RCL) mediates target protease inhibition through a conformational "suicide substrate" mechanism typical of serpins. SERPINA9 is implicated in B-cell maturation and germinal center formation. Dysregulation of SERPINA9 has been linked to B-cell malignancies, such as diffuse large B-cell lymphoma (DLBCL), where reduced expression correlates with tumor progression and immune evasion. Additionally, rare mutations may contribute to immunodeficiency disorders by disrupting protease regulation in lymphoid cells.
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技术参数
- 靶点基因名
- SERPINA9
- 基因别名
- GCET1; SERPINA11
- 蛋白别名
- serpin family A member 9; GCET1
- UniProt
- Q86WD7
- 物种
- Human
产品详情
- 靶点名称
- GCET1
- 蛋白名称
- serpin family A member 9
- 蛋白别名
- Serpin A9; Centerin; Germinal center B-cell-expressed transcript 1 protein
- 靶点基因名
- SERPINA9
- 基因别名
- GCET1; SERPINA11
- UniProt
- Q86WD7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Serpin family A member 9 (SERPINA9) is a member of the serine protease inhibitor (serpin) family, encoded by the SERPINA9 gene. This secreted glycoprotein (45.9 kDa) contains a conserved serpin domain that facilitates its role in regulating proteolytic enzymes, particularly in the endoplasmic reticulum. SERPINA9 is primarily expressed in B-lymphocytes and lymphoid tissues, where it may inhibit proteases involved in antigen processing or apoptosis. Structural studies reveal its reactive center loop (RCL) mediates target protease inhibition through a conformational "suicide substrate" mechanism typical of serpins. SERPINA9 is implicated in B-cell maturation and germinal center formation. Dysregulation of SERPINA9 has been linked to B-cell malignancies, such as diffuse large B-cell lymphoma (DLBCL), where reduced expression correlates with tumor progression and immune evasion. Additionally, rare mutations may contribute to immunodeficiency disorders by disrupting protease regulation in lymphoid cells.