人 GAS6 抗体对
01AB03408
Growth arrest specific 6 (GAS6) is a vitamin K-dependent secreted protein that serves as a high-affinity ligand for the TAM family of receptor tyrosine kinases, including Tyro-3, Axl, and Mer. Upon binding, GAS6 triggers intracellular signaling pathways that regulate diverse physiological processes such as cell survival, proliferation, migration, and phagocytosis. In the nervous system, it provides neuroprotection by promoting the survival of neurons and oligodendrocytes while simultaneously suppressing macrophage activation and the production of proinflammatory cytokines like IL-6 and TNF-alpha. GAS6 also plays a significant role in metabolic and vascular health; its dysregulation is linked to morbid obesity, glucose intolerance, and endothelial dysfunction in type 2 diabetes. Furthermore, the GAS6/TAM system is involved in modulating inflammatory responses in autoimmune demyelinating diseases, making it a key coordinator of immune homeostasis and tissue repair.
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技术参数
- 靶点基因名
- GAS6
- 基因别名
- AXLLG
- 蛋白别名
- growth arrest specific 6; GAS6
- UniProt
- Q14393
- 物种
- Human
产品详情
- 靶点名称
- GAS6
- 蛋白名称
- growth arrest specific 6
- 蛋白别名
- Growth arrest-specific protein 6; GAS-6; AXL receptor tyrosine kinase ligand
- 靶点基因名
- GAS6
- 基因别名
- AXLLG
- UniProt
- Q14393
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Growth arrest specific 6 (GAS6) is a vitamin K-dependent secreted protein that serves as a high-affinity ligand for the TAM family of receptor tyrosine kinases, including Tyro-3, Axl, and Mer. Upon binding, GAS6 triggers intracellular signaling pathways that regulate diverse physiological processes such as cell survival, proliferation, migration, and phagocytosis. In the nervous system, it provides neuroprotection by promoting the survival of neurons and oligodendrocytes while simultaneously suppressing macrophage activation and the production of proinflammatory cytokines like IL-6 and TNF-alpha. GAS6 also plays a significant role in metabolic and vascular health; its dysregulation is linked to morbid obesity, glucose intolerance, and endothelial dysfunction in type 2 diabetes. Furthermore, the GAS6/TAM system is involved in modulating inflammatory responses in autoimmune demyelinating diseases, making it a key coordinator of immune homeostasis and tissue repair.