抗人 GADD45B 抗体对
01AB02974
Growth arrest and DNA damage inducible beta (GADD45B) is a nuclear stress-response protein that plays a pivotal role in regulating cellular responses to environmental stress, growth arrest, and DNA damage. As a member of the GADD45 family, it functions by binding to upstream mitogen-activated protein kinase kinase kinases, such as MTK1/MEKK4, to modulate the p38 and JNK MAPK signaling pathways. This interaction influences critical cellular processes, including cell-cycle arrest, survival, and apoptosis. In the central nervous system, GADD45B acts as an epigenetic regulator by facilitating active DNA demethylation through base-excision repair mechanisms at specific gene promoters, such as BDNF and FGF. This activity is essential for neurogenesis, synaptic plasticity, and activity-dependent gene expression. Dysregulation of GADD45B is associated with various neuropsychiatric and neurological conditions, including autism spectrum disorders, schizophrenia, and epilepsy, as well as neurodegenerative processes in Parkinson’s disease models.
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技术参数
- 靶点基因名
- GADD45B
- 基因别名
- MYD118
- 蛋白别名
- growth arrest and DNA damage inducible beta; GADD45B
- UniProt
- O75293
- 物种
- Human
产品详情
- 靶点名称
- GADD45B
- 蛋白名称
- growth arrest and DNA damage inducible beta
- 蛋白别名
- Growth arrest and DNA damage-inducible protein GADD45 beta; Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118
- 靶点基因名
- GADD45B
- 基因别名
- MYD118
- UniProt
- O75293
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Growth arrest and DNA damage inducible beta (GADD45B) is a nuclear stress-response protein that plays a pivotal role in regulating cellular responses to environmental stress, growth arrest, and DNA damage. As a member of the GADD45 family, it functions by binding to upstream mitogen-activated protein kinase kinase kinases, such as MTK1/MEKK4, to modulate the p38 and JNK MAPK signaling pathways. This interaction influences critical cellular processes, including cell-cycle arrest, survival, and apoptosis. In the central nervous system, GADD45B acts as an epigenetic regulator by facilitating active DNA demethylation through base-excision repair mechanisms at specific gene promoters, such as BDNF and FGF. This activity is essential for neurogenesis, synaptic plasticity, and activity-dependent gene expression. Dysregulation of GADD45B is associated with various neuropsychiatric and neurological conditions, including autism spectrum disorders, schizophrenia, and epilepsy, as well as neurodegenerative processes in Parkinson’s disease models.