人 GAD2 抗体对
01AB00825
Glutamate decarboxylase 2 (GAD2), also known as GAD65, is a cytoplasmic enzyme primarily located in neurons, particularly associated with cytoplasmic vesicles, the cytosolic side of Golgi membranes, and presynaptic clusters. GAD2 catalyzes the decarboxylation of L-glutamic acid to produce gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the central nervous system, utilizing pyridoxal phosphate as a cofactor. This enzyme plays a critical role in neurotransmitter biosynthesis, synaptic transmission, and the regulation of inhibitory signaling in the brain. Clinically, GAD2 is recognized as a major autoantigen in insulin-dependent diabetes mellitus (type 1 diabetes), where autoimmune responses against this enzyme contribute to disease pathogenesis, and it has also been implicated in various neurological disorders.
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技术参数
- 靶点基因名
- GAD2
- 基因别名
- GAD65
- 蛋白别名
- glutamate decarboxylase 2; GAD2
- UniProt
- Q05329
- 物种
- Human
产品详情
- 靶点名称
- GAD2
- 蛋白名称
- glutamate decarboxylase 2
- 蛋白别名
- Glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform
- 靶点基因名
- GAD2
- 基因别名
- GAD65
- UniProt
- Q05329
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Glutamate decarboxylase 2 (GAD2), also known as GAD65, is a cytoplasmic enzyme primarily located in neurons, particularly associated with cytoplasmic vesicles, the cytosolic side of Golgi membranes, and presynaptic clusters. GAD2 catalyzes the decarboxylation of L-glutamic acid to produce gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the central nervous system, utilizing pyridoxal phosphate as a cofactor. This enzyme plays a critical role in neurotransmitter biosynthesis, synaptic transmission, and the regulation of inhibitory signaling in the brain. Clinically, GAD2 is recognized as a major autoantigen in insulin-dependent diabetes mellitus (type 1 diabetes), where autoimmune responses against this enzyme contribute to disease pathogenesis, and it has also been implicated in various neurological disorders.