抗人 GABARAPL1 抗体对
01AB02970
GABA type A receptor associated protein like 1 (GABARAP/GABARAPL1) is a ubiquitin-like modifier of the ATG8 family involved in autophagy and intracellular trafficking. Upon lipidation, it associates with autophagic membranes to facilitate phagophore elongation and mitochondrial turnover (mitophagy). GABARAPL1 also regulates the trafficking of cell surface receptors, including the GABA-A receptor and kappa opioid receptor, thereby influencing synaptic transmission and signaling. Dysregulation of GABARAPL1 is linked to breast cancer progression, where reduced expression correlates with increased invasion and metabolic reprogramming. Additionally, its role in receptor trafficking implicates it in the pathophysiology of neurological conditions such as stiff-person syndrome.
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技术参数
- 靶点基因名
- GABARAPL1
- 基因别名
- GEC1
- 蛋白别名
- GABA type A receptor associated protein like 1; GABARAPL1
- UniProt
- Q9H0R8
- 物种
- Human
产品详情
- 靶点名称
- GABARAPL1
- 蛋白名称
- GABA type A receptor associated protein like 1
- 蛋白别名
- Gamma-aminobutyric acid receptor-associated protein-like 1; Early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; Glandular epithelial cell protein 1; GEC-1
- 靶点基因名
- GABARAPL1
- 基因别名
- GEC1
- UniProt
- Q9H0R8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
GABA type A receptor associated protein like 1 (GABARAP/GABARAPL1) is a ubiquitin-like modifier of the ATG8 family involved in autophagy and intracellular trafficking. Upon lipidation, it associates with autophagic membranes to facilitate phagophore elongation and mitochondrial turnover (mitophagy). GABARAPL1 also regulates the trafficking of cell surface receptors, including the GABA-A receptor and kappa opioid receptor, thereby influencing synaptic transmission and signaling. Dysregulation of GABARAPL1 is linked to breast cancer progression, where reduced expression correlates with increased invasion and metabolic reprogramming. Additionally, its role in receptor trafficking implicates it in the pathophysiology of neurological conditions such as stiff-person syndrome.