人 G-CSF 抗体对
01AB00197
CSF3, also known as granulocyte colony-stimulating factor (G-CSF), is a gene that encodes a cytokine that plays a crucial role in the production, differentiation, and function of granulocytes, a type of white blood cell that is part of the innate immune response. The CSF3 gene is located on chromosome 17 in humans and chromosome 11 in mice. The encoded cytokine stimulates the bone marrow to produce granulocytes and release them into the bloodstream. It also promotes the survival, proliferation, and function of mature neutrophils, a type of granulocyte. Diseases associated with the CSF3 gene include neutropenia, a condition characterized by a low number of neutrophils, and mucositis, inflammation of the mucous membranes. Pharmaceutical analogs of naturally occurring G-CSF, such as filgrastim and lenograstim, are commonly used to manage chemotherapy-induced neutropenia. In addition to its role in the hematopoietic system, G-CSF has also been shown to have neurotrophic effects, promoting neurogenesis and neuroplasticity in the central nervous system.
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技术参数
- 靶点基因名
- CSF3
- 基因别名
- C17orf33; GCSF
- 蛋白别名
- colony stimulating factor 3; G-CSF
- UniProt
- P09919
- 物种
- Human
产品详情
- 靶点名称
- G-CSF
- 蛋白名称
- colony stimulating factor 3
- 蛋白别名
- Granulocyte colony-stimulating factor; G-CSF; Pluripoietin; Filgrastim; Lenograstim
- 靶点基因名
- CSF3
- 基因别名
- C17orf33; GCSF
- UniProt
- P09919
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CSF3, also known as granulocyte colony-stimulating factor (G-CSF), is a gene that encodes a cytokine that plays a crucial role in the production, differentiation, and function of granulocytes, a type of white blood cell that is part of the innate immune response. The CSF3 gene is located on chromosome 17 in humans and chromosome 11 in mice. The encoded cytokine stimulates the bone marrow to produce granulocytes and release them into the bloodstream. It also promotes the survival, proliferation, and function of mature neutrophils, a type of granulocyte. Diseases associated with the CSF3 gene include neutropenia, a condition characterized by a low number of neutrophils, and mucositis, inflammation of the mucous membranes. Pharmaceutical analogs of naturally occurring G-CSF, such as filgrastim and lenograstim, are commonly used to manage chemotherapy-induced neutropenia. In addition to its role in the hematopoietic system, G-CSF has also been shown to have neurotrophic effects, promoting neurogenesis and neuroplasticity in the central nervous system.