人 FYB 抗体对
01AB00245
FYN binding protein 1 (FYB1), also known as ADAP (Adhesion and degranulation-promoting adapter protein) and SLAP-130 (SLP-76-associated phosphoprotein), is a multifunctional protein crucial for immune cell signaling and function. It is expressed in T cells, monocytes, mast cells, macrophages, and NK cells, but not in B cells. FYB1 plays a pivotal role in post-activation T cell signaling, lymphocyte cytokine production, cell adhesion, and actin remodeling. The protein has various binding domains, including SH3 domains and a FPPP-motif that binds the ENA/VASP protein family, facilitating actin remodeling and cell adhesion processes. FYB1 is critical for the activation and proliferation of T-helper cells (CD4+) and cytotoxic T cells (CD8+), and its dysregulation has been implicated in thrombocytopenia.
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技术参数
- 靶点基因名
- FYB1
- 基因别名
- FYB; SLAP130
- 蛋白别名
- FYN binding protein 1; FYB
- UniProt
- O15117
- 物种
- Human
产品详情
- 靶点名称
- FYB
- 蛋白名称
- FYN binding protein 1
- 蛋白别名
- FYN-binding protein 1; Adhesion and degranulation promoting adaptor protein; ADAP; FYB-120/130; p120/p130; FYN-T-binding protein; SLAP-130; SLP-76-associated phosphoprotein
- 靶点基因名
- FYB1
- 基因别名
- FYB; SLAP130
- UniProt
- O15117
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
FYN binding protein 1 (FYB1), also known as ADAP (Adhesion and degranulation-promoting adapter protein) and SLAP-130 (SLP-76-associated phosphoprotein), is a multifunctional protein crucial for immune cell signaling and function. It is expressed in T cells, monocytes, mast cells, macrophages, and NK cells, but not in B cells. FYB1 plays a pivotal role in post-activation T cell signaling, lymphocyte cytokine production, cell adhesion, and actin remodeling. The protein has various binding domains, including SH3 domains and a FPPP-motif that binds the ENA/VASP protein family, facilitating actin remodeling and cell adhesion processes. FYB1 is critical for the activation and proliferation of T-helper cells (CD4+) and cytotoxic T cells (CD8+), and its dysregulation has been implicated in thrombocytopenia.