人 Furin 抗体对
01AB04034
Furin (FURIN) is a calcium-dependent serine endoprotease that plays a critical role in the post-translational modification of proteins by cleaving precursor proteins at specific polybasic sites, thus activating them. This 794-amino-acid type I transmembrane protein is widely expressed in various tissues and is involved in numerous physiological processes, including embryogenesis and hormone activation. Furin's substrates include growth factors, cytokines, and viral proteins, making it essential in both normal cellular functions and disease mechanisms. Dysregulation of FURIN has been implicated in several diseases, notably cancer, where its activity can promote tumor progression by activating growth factors and proteases that facilitate metastasis. Additionally, Furin is exploited by various pathogens, including HIV and the influenza virus, for the maturation of their envelope proteins.
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技术参数
- 靶点基因名
- FURIN
- 基因别名
- FUR; PACE; PCSK3
- 蛋白别名
- furin, paired basic amino acid cleaving enzyme; Furin
- UniProt
- P09958
- 物种
- Human
产品详情
- 靶点名称
- Furin
- 蛋白名称
- furin, paired basic amino acid cleaving enzyme
- 蛋白别名
- Furin; Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACE
- 靶点基因名
- FURIN
- 基因别名
- FUR; PACE; PCSK3
- UniProt
- P09958
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Furin (FURIN) is a calcium-dependent serine endoprotease that plays a critical role in the post-translational modification of proteins by cleaving precursor proteins at specific polybasic sites, thus activating them. This 794-amino-acid type I transmembrane protein is widely expressed in various tissues and is involved in numerous physiological processes, including embryogenesis and hormone activation. Furin's substrates include growth factors, cytokines, and viral proteins, making it essential in both normal cellular functions and disease mechanisms. Dysregulation of FURIN has been implicated in several diseases, notably cancer, where its activity can promote tumor progression by activating growth factors and proteases that facilitate metastasis. Additionally, Furin is exploited by various pathogens, including HIV and the influenza virus, for the maturation of their envelope proteins.